Despite intensive long-term efforts, with very few exceptions, the development of effective
vaccines against parasitic infections has presented considerable challenges, given the …

Malaria is a global infectious disease that remains a leading cause of morbidity and mortality
in the developing world. Multiple environmental and host and parasite factors govern the …

Malaria is caused by Plasmodium species transmitted by Anopheles mosquitoes. Following
a mosquito bite, Plasmodium sporozoites migrate from skin to liver, where extensive …

Malaria and schistosomiasis are two major parasitic diseases that remain leading causes of
morbidity and mortality worldwide. Co-infections of these two parasites are common in the …

Blood-borne pathogens can cause systemic inflammatory response syndrome (SIRS)
followed by protracted, potentially lethal immunosuppression. The mechanisms responsible …

Malaria is the one of the deadliest infectious diseases worldwide. Chemically, quinolines are
excellent ligands for metal coordination and are deployed as drugs for malaria treatment …

Malaria is one of the oldest known human diseases, and the Plasmodium genus of parasites
has plagued vertebrates for millions of years. Although five Plasmodium species infect …

Recent advances in malaria genetics and genomics have transformed many aspects of
malaria research in areas of molecular evolution, epidemiology, transmission, host–parasite …

Immunization with Plasmodium sporozoites, either attenuated or administered under the
cover of an antimalarial drug, can induce strong protection against malaria in pre-clinical …

Long-term protection against malaria remains one of the greatest challenges of vaccination
against this deadly parasitic disease. Whole-sporozoite (WSp) malaria vaccine formulations …