Neglected zoonotic diseases: Advances in the development of cell-penetrating and antimicrobial peptides against leishmaniosis and Chagas disease
SM Robledo, S Pérez-Silanes, C Fernández-Rubio… - Pathogens, 2023 - mdpi.com
In 2020, the WHO established the road map for neglected tropical diseases 2021–2030,
which aims to control and eradicate 20 diseases, including leishmaniosis and Chagas …
which aims to control and eradicate 20 diseases, including leishmaniosis and Chagas …
The midgut transcriptome of Lutzomyia longipalpis: comparative analysis of cDNA libraries from sugar-fed, blood-fed, post-digested and Leishmania infantum chagasi …
RC Jochim, CR Teixeira, A Laughinghouse, J Mu… - BMC genomics, 2008 - Springer
Background In the life cycle of Leishmania within the alimentary canal of sand flies the
parasites have to survive the hostile environment of blood meal digestion, escape the blood …
parasites have to survive the hostile environment of blood meal digestion, escape the blood …
Use of defensins to develop eco-friendly alternatives to synthetic fungicides to control phytopathogenic fungi and their mycotoxins
V Leannec-Rialland, V Atanasova, S Chereau… - Journal of Fungi, 2022 - mdpi.com
Crops are threatened by numerous fungal diseases that can adversely affect the availability
and quality of agricultural commodities. In addition, some of these fungal phytopathogens …
and quality of agricultural commodities. In addition, some of these fungal phytopathogens …
Structural and functional characterizations and heterogenous expression of the antimicrobial peptides, Hidefensins, from black soldier fly, Hermetia illucens (L.)
J Zhang, J Li, Y Peng, X Gao, Q Song, H Zhang… - Protein Expression and …, 2022 - Elsevier
Insect defensins are effector components of the innate defense system. Defensins, which are
widely distributed among insects, are a type of small cysteine-rich plant antimicrobial …
widely distributed among insects, are a type of small cysteine-rich plant antimicrobial …
Sequence characterization and expression patterns of defensin and lysozyme encoding genes from the gut of the reduviid bug Triatoma brasiliensis
CAC Araújo, PJ Waniek, P Stock, C Mayer… - Insect Biochemistry and …, 2006 - Elsevier
The cDNAs encoding an intestinal defensin (def1) and lysozyme (lys1) of the reduviid bug
Triatoma brasiliensis have been amplified by PCR using specific oligonucleotide primers …
Triatoma brasiliensis have been amplified by PCR using specific oligonucleotide primers …
Caspar-like gene depletion reduces Leishmania infection in sand fly host Lutzomyia longipalpis
EL Telleria, MRV Sant'Anna, JR Ortigão-Farias… - Journal of Biological …, 2012 - ASBMB
Female phlebotomine sand flies Lutzomyia longipalpis naturally harbor populations of the
medically important Leishmania infantum (syn. Leishmania chagasi) parasite in the gut, but …
medically important Leishmania infantum (syn. Leishmania chagasi) parasite in the gut, but …
RNAi-mediated gene silencing of Phlebotomus papatasi defensins favors Leishmania major infection
B Vomáčková Kykalová, F Sassù, P Volf… - Frontiers in …, 2023 - frontiersin.org
Introduction: Production of different antimicrobial peptides (AMPs) is one of the insect's
prominent defense strategies, regulated mainly by Toll and immune deficiency (IMD) …
prominent defense strategies, regulated mainly by Toll and immune deficiency (IMD) …
Proteophosphoglycan confers resistance of Leishmania major to midgut digestive enzymes induced by blood feeding in vector sand flies
N Secundino, N Kimblin, NC Peters… - Cellular …, 2010 - Wiley Online Library
Leishmania synthesize abundant phosphoglycan‐containing molecules made up of [Gal‐
Man‐PO4] repeating units, including the surface lipophosphoglycan (LPG), and the surface …
Man‐PO4] repeating units, including the surface lipophosphoglycan (LPG), and the surface …
Leishmania major Glycosylation Mutants Require Phosphoglycans (lpg2−) but Not Lipophosphoglycan (lpg1−) for Survival in Permissive Sand Fly Vectors
A Svárovská, TH Ant, V Seblová, L Jecná… - PLoS neglected …, 2010 - journals.plos.org
Background Sand fly species able to support the survival of the protozoan parasite
Leishmania have been classified as permissive or specific, based upon their ability to …
Leishmania have been classified as permissive or specific, based upon their ability to …
Bacterial feeding, Leishmania infection and distinct infection routes induce differential defensin expression in Lutzomyia longipalpis
EL Telleria, MRV Sant'Anna, MO Alkurbi, AN Pitaluga… - Parasites & vectors, 2013 - Springer
Background Phlebotomine insects harbor bacterial, viral and parasitic pathogens that can
cause diseases of public health importance. Lutzomyia longipalpis is the main vector of …
cause diseases of public health importance. Lutzomyia longipalpis is the main vector of …