Nanoparticle delivery platforms for RNAi therapeutics targeting COVID-19 disease in the respiratory tract
Since December 2019, a pandemic of COVID-19 disease, caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly spread across the globe. At …
respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly spread across the globe. At …
Indole-based compounds as potential drug candidates for SARS-CoV-2
AS Girgis, SS Panda, BM Kariuki, MS Bekheit… - Molecules, 2023 - mdpi.com
The COVID-19 pandemic has posed a significant threat to society in recent times,
endangering human health, life, and economic well-being. The disease quickly spreads due …
endangering human health, life, and economic well-being. The disease quickly spreads due …
One-pot synthesis, molecular docking, ADMET, and DFT studies of novel pyrazolines as promising SARS-CoV-2 main protease inhibitors
Pyrazoline and its derivatives have numerous prominent pharmacological effects. Focusing
on its anti-viral property, we have designed and synthesized three novel pyrazoline …
on its anti-viral property, we have designed and synthesized three novel pyrazoline …
Synthesis of novel antibacterial and antifungal dithiocarbamate-containing piperazine derivatives via re-engineering multicomponent approach
AZ Halimehjani, F Dehghan, V Tafakori, E Amini… - Heliyon, 2022 - cell.com
A metal-free multicomponent synthetic route for the diverse preparation of dithiocarbamate-
containing piperazine derivatives was developed through the C–N bond cleavage of …
containing piperazine derivatives was developed through the C–N bond cleavage of …
Critical review of the scientific evidence and recommendations in COVID-19 management guidelines
J Xie, Z Wang, J Liang, H Lin, Z Yang… - Open forum …, 2021 - academic.oup.com
Background Little is known about the quality and potential impacts of the guidelines for
coronavirus disease 2019 (COVID-19) management. Methods We systematically searched …
coronavirus disease 2019 (COVID-19) management. Methods We systematically searched …
Antibacterial, antibiofilm, anti-inflammatory, and wound healing effects of nanoscale multifunctional cationic alternating copolymers
Infectious diseases caused by new or unknown bacteria and viruses, such as anthrax,
cholera, tuberculosis and even COVID-19, are a major threat to humanity. Thus, the …
cholera, tuberculosis and even COVID-19, are a major threat to humanity. Thus, the …
Novel Curcumin Mimics: Design, Synthesis, Biological Properties and Computational Studies of Piperidone‐Piperazine Conjugates
MA Youssef, SS Panda, DR Aboshouk… - …, 2022 - Wiley Online Library
Di [(E)‐arylidene]‐1‐[3‐(4‐methylpiperazin‐1‐yl) alkyl] piperidin‐4‐ones 7 a− k were
synthesized through dehydrohalogenation of 1‐(2‐chloroacyl) piperidin‐4‐ones 5 a− k with …
synthesized through dehydrohalogenation of 1‐(2‐chloroacyl) piperidin‐4‐ones 5 a− k with …
Current diagnostic and therapeutic approaches for severe acute respiratory syndrome coronavirus-2 (SARS-COV-2) and the role of nanomaterial-based theragnosis …
B Zhang, Q Wu, L Yin, J Zhang, W Gao… - Nanotechnology …, 2023 - degruyter.com
COVID-19 was the most devastating pandemic since the Spanish Flu of 1918, affecting 700
million individuals and causing 6.8 million fatalities globally. COVID-19 vaccines are …
million individuals and causing 6.8 million fatalities globally. COVID-19 vaccines are …
Combined effect of traditional Chinese herbal-based formulations Jing Si herbal tea and Jing Si nasal drop inhibits adhesion and transmission of SARS-CoV2 in …
Multiple studies show increased severity of SARS-CoV2-infection in patients with
comorbidities such as hypertension and diabetes. In this study, we have prepared two …
comorbidities such as hypertension and diabetes. In this study, we have prepared two …
Identification of SARS-CoV-2 main protease inhibitors from FDA-approved drugs by artificial intelligence-supported activity prediction system
H Komatsu, T Tanaka, Z Ye, K Ikeda… - Journal of …, 2023 - Taylor & Francis
Although a certain level of efficacy and safety of several vaccine products against severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2) have been established, unmet …
acute respiratory syndrome coronavirus-2 (SARS-CoV-2) have been established, unmet …