Mesenchymal stem cells in tissue repair

AM DiMarino, AI Caplan, TL Bonfield - Frontiers in immunology, 2013 - frontiersin.org
The advent of mesenchymal stem cell (MSC)-based therapies for clinical therapeutics has
been an exciting and new innovation for the treatment of a variety of diseases associated …

Stem cells: A revolution in therapeutics—Recent advances in stem cell biology and their therapeutic applications in regenerative medicine and cancer therapies

M Mimeault, R Hauke, SK Batra - Clinical Pharmacology & …, 2007 - Wiley Online Library
Basic and clinical research accomplished during the last few years on embryonic, fetal,
amniotic, umbilical cord blood, and adult stem cells has constituted a revolution in …

MBD2 serves as a viable target against pulmonary fibrosis by inhibiting macrophage M2 program

Y Wang, L Zhang, GR Wu, Q Zhou, H Yue, LZ Rao… - Science …, 2021 - science.org
Despite past extensive studies, the mechanisms underlying pulmonary fibrosis (PF) still
remain poorly understood. Here, we demonstrated that lungs originating from different types …

Endothelial–mesenchymal transition in bleomycin-induced pulmonary fibrosis

N Hashimoto, SH Phan, K Imaizumi… - American journal of …, 2010 - atsjournals.org
The pathological hallmark lesions in idiopathic pulmonary fibrosis are the fibroblastic foci, in
which fibroblasts are thought to be involved in the tissue remodeling, matrix deposition, and …

Stem cells and cell therapies in lung biology and lung diseases

DJ Weiss, I Bertoncello, Z Borok, C Kim… - Proceedings of the …, 2011 - atsjournals.org
EXECUTIVE SUMMARY The University of Vermont College of Medicine and the Vermont
Lung Center, with support of the National Heart, Lung, and Blood Institute (NHLBI), the …

An essential role for fibronectin extra type III domain A in pulmonary fibrosis

AF Muro, FA Moretti, BB Moore, M Yan… - American journal of …, 2008 - atsjournals.org
Rationale: Tissue fibrosis is considered a dysregulated wound-healing response.
Fibronectin containing extra type III domain A (EDA) is implicated in the regulation of wound …

Pulmonary hypertension in interstitial lung disease

J Behr, JH Ryu - European Respiratory Journal, 2008 - Eur Respiratory Soc
In the lungs, parenchymal and vascular remodelling share pathomechanisms that may
explain the relatively high prevalence (30–40%) of pulmonary hypertension (PH) in …

A prospective, non-randomized, no placebo-controlled, phase Ib clinical trial to study the safety of the adipose derived stromal cells-stromal vascular fraction in …

A Tzouvelekis, V Paspaliaris, G Koliakos… - Journal of translational …, 2013 - Springer
Introduction Regenerative medicine and particular adult stem cells represent an alternative
option with several fruitful therapeutic applications in patients suffering from chronic lung …

Transplantation of allogeneic and xenogeneic placenta-derived cells reduces bleomycin-induced lung fibrosis

A Cargnoni, L Gibelli, A Tosini… - Cell …, 2009 - journals.sagepub.com
Fetal membranes (amnion and chorion) have recently raised significant attention as
potential sources of stem cells. We have recently demonstrated that cells derived from …

[HTML][HTML] Baicalin alleviates bleomycin‑induced pulmonary fibrosis and fibroblast proliferation in rats via the PI3K/AKT signaling pathway

H Zhao, C Li, L Li, J Liu, Y Gao… - Molecular …, 2020 - spandidos-publications.com
Baicalin is an important flavonoid compound THAT is isolated from the Scutellaria
baicalensis Georgi Chinese herb and plays a critical role in anti‑oxidative, anti‑inflammatory …