Activation of the innate immune system following pattern recognition receptor binding has
emerged as one of the major pathogenic mechanisms in neurodegenerative disease …

Inflammatory mechanisms are increasingly recognized as important contributors to the
pathogenesis of neurodegenerative diseases, including Lewy body dementia (LBD). Our …

Age-associated changes in the T cell compartment are well described. However, limitations
of current single-modal or bimodal single-cell assays, including flow cytometry, RNA-seq …

Aging is characterized by progressive loss of organ and tissue function, and the immune
system is no exception to that inevitable principle. Of all the age-related changes in the …

Background Energy-adjusted dietary inflammatory index (E-DII) can represent daily
inflammatory dietary components and chronic inflammatory response is an important …

Sarcopenia is an age-associated loss of skeletal muscle mass, strength, and function,
accompanied by severe adverse health outcomes, such as falls and fractures, functional …

Our traditional medical mindset and healthcare culture are being severely challenged. In the
face of novel infectious diseases, such as Coronavirus 2019 (COVID-19), along with rising …

Aging can lead to various disorders in organisms and with the escalating impact of
population aging, the incidence of age-related diseases is steadily increasing. As a major …

Malnutrition is common in older adults, and its risk is greater in those living with dementia.
Relative to cognitively healthy peers, the prevalence of malnutrition is also increased in …

Aging is the result of several complex and multifactorial processes, where several agents
contribute to an increased intrinsic vulnerability and susceptibility to age-related diseases …