Metallodrugs in medicinal inorganic chemistry

KD Mjos, C Orvig - Chemical reviews, 2014 - ACS Publications
Metal ions play important roles in biological processes, 1 and the field of knowledge
concerned with the application of inorganic chemistry to therapy or diagnosis of disease is …

Organotin (IV) dithiocarbamate complexes: Chemistry and biological activity

JO Adeyemi, DC Onwudiwe - Molecules, 2018 - mdpi.com
Significant attention has been given to organotin (IV) dithiocabamate compounds in recent
times. This is due to their ability to stabilize specific stereochemistry in their complexes, and …

“Big Three” infectious diseases: tuberculosis, malaria and HIV/AIDS

P Makam, R Matsa - Current Topics in Medicinal Chemistry, 2021 - ingentaconnect.com
Infectious diseases have been evolving and re-evolving over the ages and causing
immense misery to humans. Among them, some have been prevented and eradicated, but …

Synthesis, characterization, single crystal structure, biological evaluation of ONO donor hydrazones and their diorganotin (IV) complexes

A Boora, J Devi, T Rom, AK Paul - Journal of Molecular Structure, 2023 - Elsevier
We have synthesized a series of four ligands (H 2 L 1-H 2 L 4) and their sixteen diorganotin
(IV) complexes R''2 SnL,[R''= Me, Et, Bu, Ph]. The ligands were derived by condensation of 2 …

“Recycling” classical drugs for malaria

C Teixeira, N Vale, B Perez, A Gomes… - Chemical …, 2014 - ACS Publications
Malaria has been a human health concern ever since the dawn of mankind, but despite the
huge struggles made to date to fight this infection, in 2012 over half a million people were …

Thiosemicarbazone derivatives: Design, synthesis and in vitro antimalarial activity studies

R Matsa, P Makam, M Kaushik, SL Hoti… - European Journal of …, 2019 - Elsevier
Different types of thiosemicarbazone derivatives were designed and tested for their Drug-
Like Molecular (DLM) nature by using Lipinski and Veber rules. Subsequently, compounds …

Electrochemical Regioselective C(sp2)–H Selenylation and Sulfenylation of Substituted 2-Amino-1,4-naphthoquinones

P Karmakar, I Karmakar, D Pal, S Das… - The Journal of …, 2023 - ACS Publications
A straightforward and efficient electrochemical method for regioselective C (sp 2)–H
selenylation and sulfenylation of substituted 2-amino-1, 4-naphthoquinones has been …

Quinine conjugates and quinine analogues as potential antimalarial agents

RA Jones, SS Panda, CD Hall - European journal of medicinal chemistry, 2015 - Elsevier
Malaria is a tropical disease, prevalent in Southeast Asia and Africa, resulting in over half a
million deaths annually; efforts to develop new antimalarial agents are therefore particularly …

Exploration of artemisinin derivatives and synthetic peroxides in antimalarial drug discovery research

OPS Patel, RM Beteck, LJ Legoabe - European journal of medicinal …, 2021 - Elsevier
Malaria is a life-threatening infectious disease caused by protozoal parasites belonging to
the genus Plasmodium. It caused an estimated 405,000 deaths and 228 million malaria …

Facing diseases caused by trypanosomatid parasites: rational design of Pd and Pt complexes with bioactive ligands

D Gambino, L Otero - Frontiers in Chemistry, 2022 - frontiersin.org
Human African Trypanosomiasis (HAT), Chagas disease or American Trypanosomiasis
(CD), and leishmaniases are protozoan infections produced by trypanosomatid parasites …