Epitranscriptomic modifications in mesenchymal stem cell differentiation: advances, mechanistic insights, and beyond

J Zheng, Y Lu, Y Lin, S Si, B Guo, X Zhao… - Cell Death & …, 2024 - nature.com
RNA modifications, known as the “epitranscriptome”, represent a key layer of regulation that
influences a wide array of biological processes in mesenchymal stem cells (MSCs). These …

Non-pharmacological and drug treatment of autonomic dysfunction in multiple system atrophy: current status and future directions

BL Chen, W Yang, Y Luo, EK Tan, Q Wang - Journal of Neurology, 2023 - Springer
Multiple system atrophy (MSA) is a sporadic, fatal, and rapidly progressive
neurodegenerative disease of unknown etiology that is clinically characterized by autonomic …

[HTML][HTML] Senolytics ameliorate the failure of bone regeneration through the cell senescence-related inflammatory signalling pathway

X Wang, Y Zhou, C Luo, J Zhao, Y Ji, Z Wang… - Biomedicine & …, 2024 - Elsevier
Stress-induced premature senescent (SIPS) cells induced by various stresses deteriorate
cell functions. Dasatinib and quercetin senolytics (DQ) can alleviate several diseases by …

Age-Related Effects on MSC Immunomodulation, Macrophage Polarization, Apoptosis, and Bone Regeneration Correlate with IL-38 Expression

J Zhang, K Akiyama, AY Mun, R Tagashira… - International journal of …, 2024 - mdpi.com
Mesenchymal stem cells (MSCs) are known to promote tissue regeneration and suppress
excessive inflammation caused by infection or trauma. Reported evidence indicates that …

Mesenchymal Stem Cells in Autoimmune Disease: A Systematic Review and Meta-Analysis of Pre-Clinical Studies

HN Swain, PD Boyce, BA Bromet, K Barozinksy… - Biochimie, 2024 - Elsevier
ABSTRACT Mesenchymal Stem Cells (MSCs) are of interest in the clinic because of their
immunomodulation capabilities, capacity to act upstream of inflammation, and ability to …

Comprehensive analysis of PRPF19 immune infiltrates, DNA methylation, senescence-associated secretory phenotype and ceRNA network in bladder cancer

YX Wang, J Wang, JX He, B Ji, ZQ Pang… - Frontiers in …, 2023 - frontiersin.org
Background Pre-mRNA processing factor 19 (PRPF19) is an E3 ligase that plays a crucial
role in repairing tumor-damaged cells and promoting cell survival. However, the predictive …

Rosa roxburghii Fruit Extracts Upregulate Telomerase Activity and Ameliorate Cell Replicative Senescence

Y Huang, H Peng, Y Wu, S Deng, F Ge, W Ma, X Zhou… - Foods, 2024 - mdpi.com
Anti-aging functional foods benefit the elderly. Telomeres are chromosomal ends that
maintain genome stability extended by telomerase catalytic subunit TERT. Due to the end …

Cellular microenvironment: a key for tuning mesenchymal stem cell senescence

W Sun, J Lv, S Guo, M Lv - Frontiers in Cell and Developmental …, 2023 - frontiersin.org
Mesenchymal stem cells (MSCs) possess the ability to self-renew and differentiate into
multiple cell types, making them highly suitable for use as seed cells in tissue engineering …

Young TSPC-derived exosomal circPVT1 ameliorates aging-impaired cell function via SIRT1/NF-κB

W Han, D Gu, X Li, H Chen, X Tao, L Chen - Tissue Engineering, 2024 - liebertpub.com
Tendon stem/progenitor cell (TSPC) senescence is often associated with age-dependent
tendon diseases and greatly reduces the capacities for tendon repair and replacement …

Beclin-1 Improves the Cognitive Function of Mice with Alzheimer's Disease.

S Li, HE Qing, DU Xin, LI Qing… - Kafkas Universitesi …, 2024 - search.ebscohost.com
We aimed to investigate the improvement effect of Beclin-1 on the cognitive function of mice
with Alzheimer's disease (AD). Human umbilical cord-derived mesenchymal stem cells (hUC …