Abstract gamma-Aminobutyric acid (GABA)-mediated inhibitory neurotransmission and the
gene products involved were discovered during the mid-twentieth century. Historically …

Noncovalent interactions play a dominant role in many forefront areas of modern chemistry,
from materials design to molecular biology. A detailed understanding of the physical origin …

Fast inhibitory neurotransmission in the brain is principally mediated by the neurotransmitter
GABA (γ-aminobutyric acid) and its synaptic target, the type A GABA receptor (GABAA …

Type A γ-aminobutyric acid (GABAA) receptors are pentameric ligand-gated ion channels
and the main drivers of fast inhibitory neurotransmission in the vertebrate nervous system …

GABA A receptors are pentameric ligand-gated ion channels that mediate most fast
neuronal inhibition in the brain. In addition to their important physiological roles, they are …

γ-Aminobutyrate (GABA) is a major inhibitory neurotransmitter in the adult mammalian brain.
GABA is also considered to be a multifunctional molecule that has different situational …

GABAA receptors are ligand-gated chloride channels and ionotropic receptors of GABA, the
main inhibitory neurotransmitter in vertebrates. In this review, we discuss the major and …

The glycine receptor chloride channel (GlyR) is a member of the nicotinic acetylcholine
receptor family of ligand-gated ion channels. Functional receptors of this family comprise five …

A fragile balance between excitation and inhibition maintains the normal functioning of the
CNS. The dominant inhibitory neurotransmitter of the mammalian brain is GABA, which acts …

Autoantibodies targeting neuronal membrane proteins can cause encephalitis, seizures,
and severe behavioral abnormalities. While antibodies for several neuronal targets have …