The rampant use of antibiotics in animal husbandry, farming and clinical disease treatment
has led to a significant issue with pathogen resistance worldwide over the past decades …

Chromosomes in all domains of life are well-defined structural entities with complex
hierarchical organization. The regulation of this hierarchical organization and its functional …

In Bacteria, nucleoid structuring proteins govern nucleoid dynamics and regulate
transcription. In Shigella spp., at≤ 30° C, the histone-like nucleoid structuring protein (H-NS) …

Bdellovibrio bacteriovorus, an obligate predatory Gram-negative bacterium that proliferates
inside and kills other Gram-negative bacteria, was discovered more than 60 years ago …

The chromosome of archetypal bacteria E. coli is known for a complex topology with a 4.6×
106 base pairs (bp) long sequence of nucleotides packed within a micrometer-sized cellular …

There is increasing evidence that prokaryotes maintain chromosome structure, which in turn
impacts gene expression. We recently characterized densely occupied, multi‐kilobase …

Since the discovery of antibiotics, humans have been benefiting from them by decreasing
the morbidity and mortality associated with bacterial infections. However, in the past few …

Vibrio cholerae, the causative agent of the diarrheal disease cholera, poses an ongoing
health threat due to its wide repertoire of horizontally acquired elements (HAEs) and …

The interplay between bacterial chromosome organization and functions such as
transcription and replication can be studied in increasing detail using novel experimental …

Streptomyces are soil bacteria with complex life cycle. During sporulation Streptomyces
linear chromosomes become highly compacted so that the genetic material fits within limited …