The origins of the mesenchymal cells participating in tissue repair and pathological
processes, notably tissue fibrosis, tumor invasiveness, and metastasis, are poorly …

Glomerular podocytes are highly specialized cells with a complex cytoarchitecture. Their
most prominent features are interdigitated foot processes with filtration slits in between …

Fibrogenesis is a pathological wound repair process that fails to cease, even when the initial
insult has been removed. Fibroblasts are principal mediators of fibrosis, and fibroblasts from …

THE kidney has been widely exploited as a model system for the study of tissue inductions
regulating vertebrate organogenesis1, 2. Kidney development is initiated by the ingrowth of …

Despite the critical need for iron in many cellular reactions, deletion of the transferrin
pathway does not block organogenesis, suggesting the presence of alternative methods to …

Urogenital system development in mammals requires the coordinated differentiation of two
distinct tissues, the ductal epithelium and the nephrogenic mesenchyme, both derived from …

The mammalian kidney develops in three successive steps from the initial pronephros via
the mesonephros to the adult metanephros. Although the nephric lineage is specified during …

The scarcity of transplant allografts for diseased organs has prompted efforts at tissue
regeneration using seeded scaffolds, an approach hampered by the enormity of cell types …

A candidate gene for Branchio-Oto-Renal (BOR) syndrome was identified at chromosome
8q13. 3 by positional cloning and shown to underlie the disease. This gene is a human …

Paired box (PAX) genes play a critical role in human development and disease. The PAX2
gene is expressed in primitive cells of the kidney, ureter, eye, ear and central nervous …