The role of systems biology approaches in determining molecular signatures for the development of more effective vaccines

A Pezeshki, IG Ovsyannikova, BA McKinney… - Expert review of …, 2019 - Taylor & Francis
Introduction: Emerging infectious diseases are a major threat to public health, and while
vaccines have proven to be one of the most effective preventive measures for infectious …

[HTML][HTML] Impact of host genetic polymorphisms on response to inactivated influenza vaccine in children

TK Tsang, C Wang, NNY Tsang, VJ Fang… - npj Vaccines, 2023 - nature.com
In randomized controlled trials of influenza vaccination, 550 children received trivalent-
inactivated influenza vaccine, permitting us to explore relationship between vaccine …

Immunomics: a 21st century approach to vaccine development for complex pathogens

KP De Sousa, DL Doolan - Parasitology, 2016 - cambridge.org
Immunomics is a relatively new field of research which integrates the disciplines of
immunology, genomics, proteomics, transcriptomics and bioinformatics to characterize the …

[HTML][HTML] Principles underlying rational design of live attenuated influenza vaccines

YH Jang, BL Seong - Clinical and experimental vaccine …, 2012 - synapse.koreamed.org
Despite recent innovative advances in molecular virology and the developments of
vaccines, influenza virus remains a serious burden for human health. Vaccination has been …

Seroprevalence and durability of rubella virus antibodies in a highly immunized population

SN Crooke, IH Haralambieva, DE Grill… - Vaccine, 2019 - Elsevier
Background Although the administration of the measles-mumps-rubella (MMR) vaccine has
been widespread in the United States for decades, gaps in vaccine coverage still persist for …

Transcriptomic profiles of high and low antibody responders to smallpox vaccine

RB Kennedy, AL Oberg, IG Ovsyannikova… - Genes & …, 2013 - nature.com
Despite its eradication over 30 years ago, smallpox (as well as other orthopox viruses)
remains a pathogen of interest both in terms of biodefense and for its use as a vector for …

[HTML][HTML] The genetic regulation of infant immune responses to vaccination

MJ Newport - Frontiers in immunology, 2015 - frontiersin.org
A number of factors are recognized to influence immune responses to vaccinations including
age, gender, the dose, and quality of the antigen used, the number of doses given, the route …

[HTML][HTML] Vaccines for neglected and emerging diseases in Brazil by 2030: the “valley of death” and opportunities for RD&I in Vaccinology 4.0

A Homma, MS Freire, C Possas - Cadernos de Saúde Pública, 2020 - SciELO Public Health
We examine the implications of the very low competitiveness of the Brazilian vaccine RD&I
system, which precludes the development of all the important vaccines required by the …

Designing a multi-epitopes subunit vaccine against human herpes virus 6A based on molecular dynamics and immune stimulation

M Suleman, SH Khan, F Rashid, A Khan… - International Journal of …, 2023 - Elsevier
Abstract Human Herpesvirus 6A (HHV-6A) is a prevalent virus associated with various
clinical manifestations, including neurological disorders, autoimmune diseases, and …

Rational design of peptide vaccines against multiple types of human papillomavirus

S Dey, A De, A Nandy - Cancer informatics, 2016 - journals.sagepub.com
Human papillomavirus (HPV) occurs in many types, some of which cause cervical, genital,
and other cancers. While vaccination is available against the major cancer-causing HPV …