Innate immunological pathways in COVID-19 pathogenesis

SR Paludan, TH Mogensen - Science immunology, 2022 - science.org
Coronavirus disease 2019 (COVID-19) is a disease characterized by a profound
dysregulation of the innate immune system. This knowledge has emerged from the large …

Multifunctional role of S100 protein family in the immune system: An update

P Singh, SA Ali - Cells, 2022 - mdpi.com
S100 is a broad subfamily of low-molecular weight calcium-binding proteins (9–14 kDa) with
structural similarity and functional discrepancy. It is required for inflammation and cellular …

Immune signatures underlying post-acute COVID-19 lung sequelae

IS Cheon, C Li, YM Son, NP Goplen, Y Wu… - Science …, 2021 - science.org
Severe coronavirus disease 2019 (COVID-19) pneumonia survivors often exhibit long-term
pulmonary sequelae, but the underlying mechanisms or associated local and systemic …

The role of platelets in immune-mediated inflammatory diseases

M Scherlinger, C Richez, GC Tsokos… - Nature Reviews …, 2023 - nature.com
Immune-mediated inflammatory diseases (IMIDs) are characterized by excessive and
uncontrolled inflammation and thrombosis, both of which are responsible for organ damage …

The good and the bad: Monocytes' and macrophages' diverse functions in inflammation

J Austermann, J Roth, K Barczyk-Kahlert - Cells, 2022 - mdpi.com
Monocytes and macrophages are central players of the innate immune response and play a
pivotal role in the regulation of inflammation. Thereby, they actively participate in all phases …

Glycyrrhizic acid nanoparticles as antiviral and anti-inflammatory agents for COVID-19 treatment

Z Zhao, Y Xiao, L Xu, Y Liu, G Jiang… - … applied materials & …, 2021 - ACS Publications
COVID-19 has been diffusely pandemic around the world, characterized by massive
morbidity and mortality. One of the remarkable threats associated with mortality may be the …

Lessons learned: new insights on the role of cytokines in COVID-19

M Buszko, A Nita-Lazar, JH Park, PL Schwartzberg… - Nature …, 2021 - nature.com
In the midst of resurging COVID-19 cases, the second NIH/FDA virtual COVID-19 and
Cytokines symposium was held on 1 December 2020, focusing on longitudinal studies of …

A persistent neutrophil-associated immune signature characterizes post–COVID-19 pulmonary sequelae

PM George, A Reed, SR Desai, A Devaraj… - Science translational …, 2022 - science.org
Interstitial lung disease and associated fibrosis occur in a proportion of individuals who have
recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …

Gasdermin D-dependent platelet pyroptosis exacerbates NET formation and inflammation in severe sepsis

M Su, C Chen, S Li, M Li, Z Zeng, Y Zhang… - Nature cardiovascular …, 2022 - nature.com
Platelets have emerged as key inflammatory cells implicated in the pathology of sepsis, but
their contributions to rapid clinical deterioration and dysregulated inflammation have not …

The intersection of COVID-19 and cancer: signaling pathways and treatment implications

Z Zong, Y Wei, J Ren, L Zhang, F Zhou - Molecular cancer, 2021 - Springer
The outbreak of the novel coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as a serious public health …