The implications of exosomes in pregnancy: emerging as new diagnostic markers and therapeutics targets

M Ghafourian, R Mahdavi, Z Akbari Jonoush… - Cell Communication and …, 2022 - Springer
Extracellular vehicles (EVs) are a heterogeneous group of cell and membranous particles
originating from different cell compartments. EVs participate in many essential physiological …

Mitochondria and metabolic transitions in cardiomyocytes: lessons from development for stem cell-derived cardiomyocytes

JC Garbern, RT Lee - Stem Cell Research & Therapy, 2021 - Springer
Current methods to differentiate cardiomyocytes from human pluripotent stem cells (PSCs)
inadequately recapitulate complete development and result in PSC-derived cardiomyocytes …

Gestational leucylation suppresses embryonic T‐Box transcription factor 5 signal and causes congenital heart disease

X Zhang, L Liu, WC Chen, F Wang… - Advanced …, 2022 - Wiley Online Library
Dysregulated maternal nutrition, such as vitamin deficiencies and excessive levels of
glucose and fatty acids, increases the risk for congenital heart disease (CHD) in the …

Maternal obesity and diabetes mellitus as risk factors for congenital heart disease in the offspring

E Helle, JR Priest - Journal of the American Heart Association, 2020 - Am Heart Assoc
Congenital heart disease (CHD) is the most common anatomical malformation occurring live‐
born infants and an increasing cause of morbidity and mortality across the lifespan and …

Immunoendocrine dysregulation during gestational diabetes mellitus: The central role of the placenta

A Olmos-Ortiz, P Flores-Espinosa, L Díaz… - International Journal of …, 2021 - mdpi.com
Gestational Diabetes Mellitus (GDM) is a transitory metabolic condition caused by
dysregulation triggered by intolerance to carbohydrates, dysfunction of beta-pancreatic and …

Environmental risk factors for congenital heart disease

JI Kalisch-Smith, N Ved… - Cold Spring Harbor …, 2020 - cshperspectives.cshlp.org
Congenital heart disease (CHD) has many forms and a wide range of causes. Clinically, it is
important to understand the causes. This allows estimation of recurrence rate, guides …

Association between maternal factors and risk of congenital heart disease in offspring: a systematic review and meta-analysis

L Wu, N Li, Y Liu - Maternal and Child Health Journal, 2023 - Springer
Introduction This study aimed to summarize the evidence describing the relationship
between maternal factors during gestation and risk of congenital heart disease (CHD) in …

[HTML][HTML] Genetics of congenital heart disease: a narrative review of recent advances and clinical implications

J Yasuhara, V Garg - Translational Pediatrics, 2021 - ncbi.nlm.nih.gov
Congenital heart disease (CHD) is the most common human birth defect and remains a
leading cause of mortality in childhood. Although advances in clinical management have …

[HTML][HTML] Cardiac changes in infants of diabetic mothers

M Al-Biltagi, D El Amrousy - World Journal of Diabetes, 2021 - ncbi.nlm.nih.gov
Diabetes mellitus (DM) is a systemic chronic metabolic disorder characterized by increased
insulin resistance and/or β-cell defects. It affects all ages from the foetal life, neonates …

Metabolic disease programming: from mitochondria to epigenetics, glucocorticoid signalling and beyond

LF Grilo, C Tocantins, MS Diniz… - European journal of …, 2021 - Wiley Online Library
Embryonic and foetal development are critical periods of development in which several
environmental cues determine health and disease in adulthood. Maternal conditions and an …