Purpose of review A polygenic risk score (PRS) is a measure of genetic liability to a disease
and is typically normally distributed in a population. Individuals in the upper tail of this …

The clinically heterogeneous presentation of schizophrenia is compounded by the
heterogeneity of risk factors and neurobiological correlates of the disorder. Genome-wide …

Genome-wide association studies (GWAS) in admixed populations such as African
Americans (AA) have limited sample sizes, resulting in poor performance of polygenic risk …

Each human, when born, has slightly different DNA sequences, which make each of us
unique. The variations in DNA sequences are called genetic variants. The primary aim of …

Genome-wide association studies (GWAS) have revolutionized our ability to understand the
genetic underpinnings of biomedical traits; however, their extreme Eurocentric bias has …

Since 2005, thousands of genome-wide association studies (GWAS) have been published,
identifying hundreds of thousands of genetic variants that increase risk of complex traits …

Genomics research has improved our understanding of the genetic basis for human traits
and diseases. This progress is now being translated into clinical care as we move toward a …

Determining effective means of preventing Multiple Sclerosis (MS) relies on testing
preventive strategies in trial populations. However, because of the low incidence of MS …

Background: End-stage knee osteoarthritis (OA) is a highly debilitating disease for which
total knee arthroplasty (TKA) serves as an effective treatment option. Although a genetic …

Abstract Genome-wide Association Studies (GWAS) have identified more than 300 loci
associated with coronary artery disease (CAD), defining the genetic risk map of the disease …