In this perspective we discuss the current lack of genetic and environmental diversity in
functional genomics datasets. There is a well-described Eurocentric bias in genetic and …

The recent commercialization of the Embryo Health Score (EHS), determined through
preimplantation genetic testing for polygenic conditions, offers the potential to select …

Possessing informative tools to predict who is most at risk for antisocial behavior in
adolescence is important to help identify families most in need of early intervention …

Linkage disequilibrium (LD) is a fundamental concept in genetics; critical for studying
genetic associations and molecular evolution. However, LD measurements are only reliable …

Epigenetics underpins the regulation of genes known to play a key role in the adaptive and
innate immune system (AIIS). We developed a method, EpiNN, that leverages epigenetic …

Abstract Purpose of Review Coronary artery disease (CAD) is a common and etiologically
complex disease worldwide. Current guidelines for primary prevention, or the prevention of …

Human genetics has emerged as one of the most dynamic areas of biology, with a
broadening societal impact. In this review, we discuss recent achievements, ongoing efforts …

Prostate cancer is a heritable disease with ancestry-biased incidence and mortality.
Polygenic risk scores (PRSs) offer promising advancements in predicting disease risk …

Context Functional genomics studies have highlighted genomic regions with regulatory and
evolutionary significance. Such information independent of association analysis may benefit …

Private companies have begun offering services to allow parents undergoing in-vitro
fertilisation to screen embryos for genetic risk of complex diseases, including psychiatric …