Human cytomegalovirus genomics and transcriptomics through the lens of next-generation sequencing: revision and future challenges

J Martí-Carreras, P Maes - Virus Genes, 2019 - Springer
The human cytomegalovirus (HCMV) genome was sequenced by hierarchical shotgun
almost 30 years ago. Over these years, low and high passaged strains have been …

Neutralization of diverse human cytomegalovirus strains conferred by antibodies targeting viral gH/gL/pUL128-131 pentameric complex

S Ha, F Li, MC Troutman, DC Freed, A Tang… - Journal of …, 2017 - Am Soc Microbiol
Human cytomegalovirus (HCMV) is the leading cause of congenital viral infection, and
developing a prophylactic vaccine is of high priority to public health. We recently reported a …

A replication-defective human cytomegalovirus vaccine elicits humoral immune responses analogous to those with natural infection

Y Liu, DC Freed, L Li, A Tang, F Li, EM Murray… - Journal of …, 2019 - Am Soc Microbiol
Human cytomegalovirus (HCMV) can cause congenital infections, which are a leading
cause of childhood disabilities. Since the rate of maternal-fetal transmission is much lower in …

Impact of antibodies and strain polymorphisms on cytomegalovirus entry and spread in fibroblasts and epithelial cells

X Cui, DC Freed, D Wang, P Qiu, F Li, TM Fu… - Journal of …, 2017 - Am Soc Microbiol
Cytomegalovirus (CMV) entry into fibroblasts differs from entry into epithelial cells. CMV also
spreads cell to cell and can induce syncytia. To gain insights into these processes, 27 …

Recognition of a highly conserved glycoprotein B epitope by a bivalent antibody neutralizing HCMV at a post-attachment step

X Ye, H Su, D Wrapp, DC Freed, F Li, Z Yuan… - PLoS …, 2020 - journals.plos.org
Human cytomegalovirus (HCMV) is one of the main causative agents of congenital viral
infection in neonates. HCMV infection also causes serious morbidity and mortality among …

Association of CMV genomic mutations with symptomatic infection and hearing loss in congenital CMV infection

GC Dobbins, A Patki, D Chen, HK Tiwari… - BMC Infectious …, 2019 - Springer
Background Congenital cytomegalovirus (cCMV) infection is the most common congenital
infection and a leading cause of long-term neurological and sensory sequelae, the most …

[HTML][HTML] Subconfluent ARPE-19 Cells Display Mesenchymal Cell-State Characteristics and Behave like Fibroblasts, Rather Than Epithelial Cells, in Experimental …

P Golconda, M Andrade-Medina, A Oberstein - Viruses, 2023 - mdpi.com
Human cytomegalovirus (HCMV) has a broad cellular tropism and epithelial cells are
important physiological targets during infection. The retinal pigment epithelial cell line ARPE …

Antiviral resistance and persistent replication of cytomegalovirus and SARS-CoV-2 in immunocompromised patients

M Santos Bravo - 2022 - diposit.ub.edu
[eng] The main objectives of this thesis are to study the opportunistic infection caused by
human cytomegalovirus and SARS-CoV-2 inquiring persistent infection and antiviral …

[图书][B] Investigation of the Pathogenic Role of Human Cytomegalovirus Glycoprotein Polymorphisms in Congenital Infections

AM Alharbi - 2020 - search.proquest.com
Background: Human cytomegalovirus (HCMV) is the most prevalent cause of congenital
infections, non-hereditary sensorineural hearing loss and other serious neurological …