[HTML][HTML] CAR T cells: engineered immune cells to treat brain cancers and beyond

Z Huang, S Dewanjee, P Chakraborty, NK Jha, A Dey… - Molecular cancer, 2023 - Springer
Malignant brain tumors rank among the most challenging type of malignancies to manage.
The current treatment protocol commonly entails surgery followed by radiotherapy and/or …

Three Strategies in Engineering Nanomedicines for Tumor Microenvironment‐Enabled Phototherapy

S He, X Jia, S Feng, J Hu - Small, 2023 - Wiley Online Library
Canonical phototherapeutics have several limitations, including a lack of tumor selectivity,
nondiscriminatory phototoxicity, and tumor hypoxia aggravation. The tumor …

The battle of lipid-based nanocarriers against blood-brain barrier: A critical review

KK Abla, MM Mehanna - Journal of Drug Targeting, 2023 - Taylor & Francis
Central nervous system integrity is the state of brain functioning across sensory, cognitive,
emotional-social behaviors, and motor domains, allowing a person to realise his full …

[HTML][HTML] Bilirubin and redox stress in age-related brain diseases

JP Llido, S Jayanti, C Tiribelli, S Gazzin - Antioxidants, 2023 - mdpi.com
Cellular redox status has a crucial role in brain physiology, as well as in pathologic
conditions. Physiologic senescence, by dysregulating cellular redox homeostasis and …

Formulation of double nanoemulsions based on pH-sensitive carboxymethyl cellulose/Starch copper doped carbon quantum dots for quercetin controlled release

M Najafi, M Pourmadadi, M Abdous, A Rahdar… - Journal of Molecular …, 2024 - Elsevier
Nanocomposite Hydrogels are versatile and adaptable in drug delivery, suitable for various
administrations. They offer prolonged and regulated drug release which makes them …

Hypericum alpestre extract exhibits in vitro and in vivo anticancer properties by regulating the cellular antioxidant system and metabolic pathway of L‐arginine

M Ginovyan, H Javrushyan… - Cell Biochemistry …, 2024 - Wiley Online Library
Conventional treatment methods are not effective enough to fight the rapid increase in
cancer cases. The interest is increasing in the investigation of herbal sources for the …

Detection of new phytochemical compounds from Vassobia breviflora (Sendtn.) Hunz: antioxidant, cytotoxic, and antibacterial activity of the hexane extract

A Rossato Viana, B Godoy Noro, D Santos… - Journal of Toxicology …, 2023 - Taylor & Francis
ABSTRACT Vassobia breviflora (Sendtn.) Hunz is a plant of the Solanaceae family from
South America and there are no apparent studies reported on the biological activity of the …

[HTML][HTML] Dysregulated lipid metabolism in TMZ-resistant glioblastoma: Pathways, proteins, metabolites and therapeutic opportunities

TJ Kao, CL Lin, WB Yang, HY Li, TI Hsu - Lipids in Health and Disease, 2023 - Springer
Glioblastoma (GBM) is a highly aggressive and lethal brain tumor with limited treatment
options, such as the chemotherapeutic agent, temozolomide (TMZ). However, many GBM …

[HTML][HTML] Regulatory roles of flavonoids in caspase-11 non-canonical inflammasome-mediated inflammatory responses and diseases

YS Yi - International Journal of Molecular Sciences, 2023 - mdpi.com
Inflammasomes are multiprotein complexes that activate inflammatory responses by
inducing pyroptosis and secretion of pro-inflammatory cytokines. Along with many previous …

[HTML][HTML] In Vitro Evaluation of Ferutinin Rich-Ferula communis L., ssp. glauca, Root Extract on Doxorubicin-Induced Cardiotoxicity: Antioxidant Properties and Cell …

R Macrì, I Bava, F Scarano, R Mollace… - International Journal of …, 2023 - mdpi.com
The clinical use of anthracycline Doxorubicin as an antineoplastic drug in cancer therapy is
limited by cardiotoxic effects that can lead to congestive heart failure. Recent studies have …