Deletion of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) envelope (E) gene attenuates the virus. E gene encodes a small multifunctional protein that possesses …
Severe acute respiratory syndrome coronavirus (SARS-CoV) is the etiological agent of a respiratory disease that has a 10% mortality rate. We previously showed that SARS-CoV …
A Abdel Moneim, MA Radwan… - Current Medical Research …, 2022 - Taylor & Francis
Abstract The coronavirus disease 2019 (COVID-19) pandemic is caused by a new coronavirus family member, severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
A recombinant severe acute respiratory syndrome coronavirus (SARS-CoV) lacking the envelope (E) protein is attenuated in vivo. Here we report that E protein PDZ-binding motif …
Z Zeng, L Xu, XY Xie, HL Yan, BJ Xie, WZ Xu… - …, 2020 - Wiley Online Library
Aims An ongoing outbreak of 2019 novel coronavirus (CoV) disease (COVID‐19), caused by severe acute respiratory syndrome (SARS) CoV‐2, has been spreading in multiple …
Key points We report a novel method for the transient expression of SARS‐CoV‐2 envelope (E) protein in intracellular organelles and the plasma membrane of mammalian cells and …
A SARS-CoV lacking the full-length E gene (SARS-CoV-∆ E) was attenuated and an effective vaccine. Here, we show that this mutant virus regained fitness after serial passages …
K Martinez Lagunas, DP Savcigil, M Zrilic… - Science …, 2023 - science.org
Cell death coordinates repair programs following pathogen attack and tissue injury. However, aberrant cell death can interfere with such programs and cause organ failure …
HY Lee, J Ahn, J Park, C Kyung Kang… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Although statins are widely prescribed lipid-lowering drugs, there are concerns about the safety of their use in the context of coronavirus disease 2019 (COVID-19), since …