Regulation of Sirt1 on energy metabolism and immune response in rheumatoid arthritis

Y Wu, W Fang, S Pan, S Zhang, D Li, Z Wang… - International …, 2021 - Elsevier
Rheumatoid arthritis (RA) is a systemic autoimmune disease. Synovial hyperplasia and
persistent inflammation serve as its typical pathological manifestations, which ultimately lead …

Metabolic reprogramming as a key regulator in the pathogenesis of rheumatoid arthritis

W Cai, Y Yu, S Zong, F Wei - Inflammation Research, 2020 - Springer
Purpose Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease with synovitis
as pathological changes. The immune microenvironment of RA promotes metabolic …

Panax notoginseng saponins (PNS) attenuate Th17 cell differentiation in CIA mice via inhibition of nuclear PKM2-mediated STAT3 phosphorylation

MY Shen, YX Di, X Wang, FX Tian, MF Zhang… - Pharmaceutical …, 2023 - Taylor & Francis
Context Rheumatoid arthritis (RA) is an autoimmune disease with aberrant Th17 cell
differentiation. Panax notoginseng (Burk.) FH Chen (Araliaceae) saponins (PNS) have an …

Integrative computational approach identifies drug targets in CD4+ T-cell-mediated immune disorders

BL Puniya, R Amin, B Lichter, R Moore… - NPJ systems biology …, 2021 - nature.com
CD4+ T cells provide adaptive immunity against pathogens and abnormal cells, and they
are also associated with various immune-related diseases. CD4+ T cells' metabolism is …

[HTML][HTML] Targeting immunometabolism by active ingredients derived from traditional Chinese medicines for treatment of rheumatoid arthritis

Y He, C Mai, H Pan, L Liu, H Zhou, Y Xie - Chinese Herbal Medicines, 2021 - Elsevier
Rheumatoid arthritis (RA), the most common inflammatory arthropathy word wild, is a
systemic autoimmune disease that mainly affects the synovium of joints with a high disability …

Identification of metabolic biomarkers in relation to methotrexate response in early rheumatoid arthritis

HR Gosselt, IB Muller, G Jansen… - Journal of personalized …, 2020 - mdpi.com
This study aimed to identify baseline metabolic biomarkers for response to methotrexate
(MTX) therapy in rheumatoid arthritis (RA) using an untargeted method. In total, 82 baseline …

Consumption of saturated fatty acids‐rich lard benefits recovery of experimental arthritis by activating PPAR‐γ

R Wang, CL Ji, DD Feng, YJ Wu, Y Li… - Molecular Nutrition & …, 2023 - Wiley Online Library
Scope This study investigates the impacts of lard and related fatty acids intake on
rheumatoid arthritis (RA) animal models. Method and results Collagen‐induced arthritis …

AMPK/SIRT1 deficiency drives adjuvant-induced arthritis in rats by promoting glycolysis-mediated monocytes inflammatory polarization

DD Wang, CY He, YJ Wu, L Xu, C Shi… - Journal of …, 2022 - Taylor & Francis
Background Exact roles of many metabolic regulators in rheumatoid arthritis (RA) are to be
clarified. This study aimed to further characterize the impacts of silent information regulator 1 …

Interleukin-17 contributes to Ross River virus-induced arthritis and myositis

H Mostafavi, K Tharmarajah, J Vider, NP West… - PLoS …, 2022 - journals.plos.org
Arthritogenic alphaviruses are mosquito-borne viruses that are a major cause of infectious
arthropathies worldwide, and recent outbreaks of chikungunya virus and Ross River virus …

Metabolic changes in fibroblast-like synoviocytes in rheumatoid arthritis: state of the art review

Z Hu, Y Li, L Zhang, Y Jiang, C Long, Q Yang… - Frontiers in …, 2024 - frontiersin.org
Fibroblast-like synoviocytes (FLS) are important components of the synovial membrane.
They can contribute to joint damage through crosstalk with inflammatory cells and direct …