Inflammatory bowel disease (IBD) is a complex genetic disease that is instigated and
amplified by the confluence of multiple genetic and environmental variables that perturb the …

The C-type lectins are a superfamily of proteins that recognize a broad repertoire of ligands
and that regulate a diverse range of physiological functions. Most research attention has …

Genome-wide association studies (GWASs) have identified hundreds of loci associated with
Crohn's disease (CD). However, as with all complex diseases, robust identification of the …

Protein ubiquitination has become one of the most extensively studied post-translational
modifications. Originally discovered as a critical element in highly regulated proteolysis …

The gut microbiome is at the center of inflammatory bowel disease (IBD) pathogenesis and
disease activity. While this has mainly been studied in the context of the bacterial …

In the 21st century, urbanization represents a major demographic shift in developed and
developing countries. Rapid urbanization in the developing world has been associated with …

INTRODUCTION Inhibition of oncogenic proteins represents a mainstay approach for cancer
therapeutic development. By contrast, pharmacological modulation of tumor suppressor …

Genome-wide association studies have identified> 10,000 genetic variants associated with
various phenotypes and diseases. Although the majority are common variants, rare variants …

Spleen tyrosine kinase (SYK) is a critical immune signaling molecule and therapeutic target.
We identified damaging monoallelic SYK variants in six patients with immune deficiency …

Abstract CARD protein–BCL-10–MALT1 (CBM) signalosomes are multiprotein signalling
platforms that control immune and inflammatory pathways in most tissues. After exposure to …