Advances in nanomaterial-based platforms to combat COVID-19: Diagnostics, preventions, therapeutics, and vaccine developments

N Mahmud, MI Anik, MK Hossain, MI Khan… - ACS Applied Bio …, 2022 - ACS Publications
The COVID-19 pandemic caused by the SARS-CoV-2, a ribonucleic acid (RNA) virus that
emerged less than two years ago but has caused nearly 6.1 million deaths to date. Recently …

Nanobodies: robust miniprotein binders in biomedicine

JYJ Kim, Z Sang, Y Xiang, Z Shen, Y Shi - Advanced Drug Delivery …, 2023 - Elsevier
Variable domains of heavy chain-only antibodies (VHH), also known as nanobodies (Nbs),
are monomeric antigen-binding domains derived from the camelid heavy chain-only …

Targeted drug delivery using nanobodies to deliver effective molecules to breast cancer cells: the most attractive application of nanobodies

MH Abdolvahab, P Karimi, N Mohajeri, M Abedini… - Cancer Cell …, 2024 - Springer
Targeted drug delivery is one of the attractive ways in which cancer treatment can
significantly reduce side effects. In the last two decades, the use of antibodies as a tool for …

Superimmunity by pan-sarbecovirus nanobodies

Y Xiang, W Huang, H Liu, Z Sang, S Nambulli… - Cell Reports, 2022 - cell.com
Vaccine boosters and infection can facilitate the development of SARS-CoV-2 antibodies
with improved potency and breadth. Here, we observe superimmunity in a camelid …

Therapeutic applications of nanobodies against SARS-CoV-2 and other viral infections: Current update

M Bhattacharya, S Chatterjee, SS Lee… - International Journal of …, 2023 - Elsevier
In the last two years, the world encountered the SARS-CoV-2 virus, which is still dominating
the population due to the absence of a viable treatment. To eradicate the global pandemic …

Broad Sarbecovirus Neutralizing Antibodies Obtained by Computational Design and Synthetic Library Screening

X Yang, H Duan, X Liu, X Zhang, S Pan… - Journal of …, 2023 - Am Soc Microbiol
Members of the Sarbecovirus subgenus of Coronaviridae have twice caused deadly threats
to humans. There is increasing concern about the rapid mutation of severe acute respiratory …

NANOBODY® Molecule, a Giga Medical Tool in Nanodimensions

S Kunz, M Durandy, L Seguin, CC Feral - International Journal of …, 2023 - mdpi.com
Although antibodies remain the most widely used tool for biomedical research, antibody
technology is not flawless. Innovative alternatives, such as Nanobody® molecules, were …

The (apparent) antibody paradox in COVID-19

R Ameratunga, ST Woon, E Lea, R Steele… - Expert Review of …, 2022 - Taylor & Francis
Introduction The immunological response to COVID-19 is only partly understood. It is
increasingly clear that the virus triggers an inappropriate host inflammatory reaction in …

Nanobodies; new molecular instruments with special specifications for targeting, diagnosis and treatment of triple-negative breast cancer

H Bakherad, F Ghasemi, M Hosseindokht… - Cancer Cell …, 2022 - Springer
Breast cancer is the most common type of cancer in women and the second leading cause
of cancer death in female. Triple-negative breast cancer has a more aggressive proliferation …

[HTML][HTML] Transcriptomics secondary analysis of severe human infection with SARS-CoV-2 identifies gene expression changes and predicts three transcriptional …

J Clancy, CS Hoffmann, BE Pickett - Computational and Structural …, 2023 - Elsevier
SARS-CoV-2 is the causative agent of COVID-19, which has greatly affected human health
since it first emerged. Defining the human factors and biomarkers that differentiate severe …