Bioprinting: From Tissue and Organ Development to in Vitro Models
Bioprinting techniques have been flourishing in the field of biofabrication with pronounced
and exponential developments in the past years. Novel biomaterial inks used for the …
and exponential developments in the past years. Novel biomaterial inks used for the …
Development of the mammalian kidney
AP McMahon - Current topics in developmental biology, 2016 - Elsevier
The basic unit of kidney function is the nephron. In the mouse, around 14,000 nephrons form
in a 10-day period extending into early neonatal life, while the human fetus forms the adult …
in a 10-day period extending into early neonatal life, while the human fetus forms the adult …
Spatiotemporal immune zonation of the human kidney
Tissue-resident immune cells are important for organ homeostasis and defense. The
epithelium may contribute to these functions directly or by cross-talk with immune cells. We …
epithelium may contribute to these functions directly or by cross-talk with immune cells. We …
Kidney decellularized extracellular matrix enhanced the vascularization and maturation of human kidney organoids
JW Kim, SA Nam, J Yi, JY Kim, JY Lee… - Advanced …, 2022 - Wiley Online Library
Kidney organoids derived from human pluripotent stem cells (hPSCs) have extensive
potential for disease modelling and regenerative medicine. However, the limited …
potential for disease modelling and regenerative medicine. However, the limited …
3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening
The podocytes within the glomeruli of the kidney maintain the filtration barrier by forming
interdigitating foot processes with intervening slit diaphragms, disruption in which results in …
interdigitating foot processes with intervening slit diaphragms, disruption in which results in …
Human organ-specific endothelial cell heterogeneity
The endothelium first forms in the blood islands in the extra-embryonic yolk sac and then
throughout the embryo to establish circulatory networks that further acquire organ-specific …
throughout the embryo to establish circulatory networks that further acquire organ-specific …
Human induced pluripotent stem cell–derived podocytes mature into vascularized glomeruli upon experimental transplantation
Glomerular podocytes express proteins, such as nephrin, that constitute the slit diaphragm,
thereby contributing to the filtration process in the kidney. Glomerular development has been …
thereby contributing to the filtration process in the kidney. Glomerular development has been …
Organoids from nephrotic disease-derived iPSCs identify impaired NEPHRIN localization and slit diaphragm formation in kidney podocytes
Mutations in the NPHS1 gene, which encodes NEPHRIN, cause congenital nephrotic
syndrome, resulting from impaired slit diaphragm (SD) formation in glomerular podocytes …
syndrome, resulting from impaired slit diaphragm (SD) formation in glomerular podocytes …
The evolving complexity of the podocyte cytoskeleton
C Schell, TB Huber - Journal of the American Society of …, 2017 - journals.lww.com
Podocytes exhibit a unique cytoskeletal architecture that is fundamentally linked to their
function in maintaining the kidney filtration barrier. The cytoskeleton regulates podocyte …
function in maintaining the kidney filtration barrier. The cytoskeleton regulates podocyte …
Nephrin signaling in the podocyte: an updated view of signal regulation at the slit diaphragm and beyond
Podocytes are a major component of the glomerular blood filtration barrier, and alterations to
the morphology of their unique actin-based foot processes (FP) are a common feature of …
the morphology of their unique actin-based foot processes (FP) are a common feature of …