Influenza infection, SARS, MERS and COVID-19: cytokine storm–the common denominator and the lessons to be learned

VA Ryabkova, LP Churilov, Y Shoenfeld - Clinical Immunology, 2021 - Elsevier
The outbreak of COVID-19 reminds us that the emerging and reemerging respiratory virus
infections pose a continuing threat to human life. Cytokine storm syndromes of viral origin …

Associations between Serum Interleukins (IL‐1β, IL‐2, IL‐4, IL‐6, IL‐8, and IL‐10) and Disease Severity of COVID‐19: A Systematic Review and Meta‐Analysis

Y Chang, M Bai, Q You - BioMed Research International, 2022 - Wiley Online Library
Background. To investigate the association between interleukins (IL‐1β, IL‐2, IL‐4, IL‐6, IL‐
8, and IL‐10) and the disease severity of coronavirus disease 2019 (COVID‐19). Materials …

Nexus between COVID-19 and periodontal disease

K Sukumar, A Tadepalli - Journal of International Medical …, 2021 - journals.sagepub.com
Over the past several decades, studies have demonstrated the existence of bi-directional
relationships between periodontal disease and systemic conditions. Periodontitis is a …

Role of host immune and inflammatory responses in COVID-19 cases with underlying primary immunodeficiency: a review

BM Liu, HR Hill - Journal of Interferon & Cytokine Research, 2020 - liebertpub.com
Coronavirus disease 2019 (COVID-19) has spread rapidly and become a pandemic.
Caused by a novel human coronavirus called severe acute respiratory syndrome …

Point‐of‐care detection of cytokines in cytokine storm management and beyond: Significance and challenges

G Liu, C Jiang, X Lin, Y Yang - View, 2021 - Wiley Online Library
Cytokines are signaling molecules between cells in immune system. Cytokine storm, due to
the sudden acute increase in levels of pro‐inflammatory circulating cytokines, can result in …

Longitudinal single cell atlas identifies complex temporal relationship between type I interferon response and COVID-19 severity

QXX Lin, D Rajagopalan, AM Gamage, LM Tan… - Nature …, 2024 - nature.com
Due to the paucity of longitudinal molecular studies of COVID-19, particularly those covering
the early stages of infection (Days 1-8 symptom onset), our understanding of host response …

Integrated immunovirological profiling validates plasma SARS-CoV-2 RNA as an early predictor of COVID-19 mortality

E Brunet-Ratnasingham, SP Anand, P Gantner… - Science …, 2021 - science.org
Despite advances in COVID-19 management, identifying patients evolving toward death
remains challenging. To identify early predictors of mortality within 60 days of symptom …

Population-weighted exposure to green spaces tied to lower COVID-19 mortality rates: A nationwide dose-response study in the USA

Y Yang, Y Lu, B Jiang - Science of The Total Environment, 2022 - Elsevier
The COVID-19 pandemic has caused a huge loss of human life globally. However, few
studies investigated the link between exposure to green space and risk of COVID-19 …

Ecology and machine learning-based classification models of gut microbiota and inflammatory markers may evaluate the effects of probiotic supplementation in …

L Laterza, L Putignani, CR Settanni, V Petito… - International Journal of …, 2023 - mdpi.com
Gut microbiota (GM) modulation can be investigated as possible solution to enhance
recovery after COVID-19. An open-label, single-center, single-arm, pilot, interventional study …

Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responses

A Banerjee, N El-Sayes, P Budylowski, RA Jacob… - IScience, 2021 - cell.com
Type I interferons (IFNs) are our first line of defense against virus infection. Recent studies
have suggested the ability of SARS-CoV-2 proteins to inhibit IFN responses. Emerging data …