Cellular senescence is a state of stable, terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …

Both aging and cancer are characterized by a series of partially overlapping" hallmarks" that
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …

Stem cells play central roles in tissue development, homeostasis, and regeneration.
Decades of scientific research have uncovered processes of stem cell decline in tissue and …

Cellular senescence is a critical stress response program implicated in embryonic
development, wound healing, aging, and immunity, and it backs up apoptosis as an ultimate …

The receptor activator of the nuclear factor-κB ligand (RANKL)/RANK signaling pathway was
identified in the late 1990s and is the key mediator of bone remodeling. Targeting RANKL …

The RANK–RANKL–OPG system is a complex signaling pathway that plays a critical role in
bone metabolism, mammary epithelial cell development, immune function, and cancer …

The functional capacity of organisms declines in the process of aging. In the case of breast
tissue, abnormal mammary gland development can lead to dysfunction in milk secretion, a …

Simple Summary Nowadays, the upfront treatment for patients facing a diagnosis of
advanced luminal breast cancer (BC) is a combination of endocrine therapy (ET) with an …

The origin of cancer remains one of the most important enigmas in modern biology. This
paper presents a hypothesis for the origin of carcinomas in which cellular aging and …

Rank signaling pathway regulates mammary gland homeostasis and epithelial cell
differentiation. Although Rank receptor is expressed by basal cells and luminal progenitors …