BEN domain–containing proteins are emerging rapidly as an important class of factors
involved in modulating gene expression, yet the molecular basis of how they regulate …

Genome stability requires tight regulation of DNA replication to ensure that the entire
genome of the cell is duplicated once and only once per cell cycle. In mammalian cells …

In metazoan cells, DNA replication initiates from thousands of genomic loci scattered
throughout the genome called DNA replication origins. Origins are strongly associated with …

DNA replication starts with the opening of DNA at sites called DNA replication origins. From
the single sequence-specific DNA replication origin of the small Escherichia coli genome, up …

In eukaryotic genomes, hundreds to thousands of potential start sites of DNA replication
named origins are dispersed across each of the linear chromosomes. During S-phase, only …

Genomic DNA replicates according to a defined temporal program in which early-replicating
loci are associated with open chromatin, higher gene density, and increased gene …

Background Next-generation sequencing allows genome-wide analysis of changes in
chromatin states and gene expression. Data analysis of these increasingly used methods …

Mammalian chromosome duplication progresses in a precise order and is subject to
constraints that are often relaxed in developmental disorders and malignancies. Molecular …

A major obstacle in understanding the complex biology of the malaria parasite remains to
discover how gene transcription is controlled during its life cycle. Accumulating evidence …

Cellular plasticity of cancer cells is often associated with phenotypic heterogeneity and drug
resistance and thus remains a major challenge for the treatment of melanoma and other …