Macrocyclization of peptides reduces conformational flexibilities, potentially leading to
improved drug-like properties, such as target specificities and metabolic stabilities. As …

Penicillin-binding protein-type thioesterases (PBP-type TEs) are a recently identified group
of peptide cyclases that catalyze head-to-tail macrolactamization of nonribosomal peptides …

Whole-genome sequencing and bioinformatics analyses have shown that the potential of
synthesizing secondary metabolites from marine-derived Streptomyces has been …

Burkholderia pseudomallei is the Gram-negative bacterium that cause infection termed
“Melioidosis”[ 1, 2]. It widely dominates soil as well as water surface and could easily be …

Pentaminomycins F–H (1–3), a group of three new hydroxyarginine-containing cyclic
pentapeptides, were isolated from cultures of a Streptomyces cacaoi subsp. cacaoi strain …

微生物作为天然产物的巨大宝库, 一直以来都是研究人员挖掘和开发新的活性化合物的重要来源
. 目前, 利用基因编辑工具发现, 生物合成和代谢调控天然产物的研究方法受到该领域研究者的 …

Microorganisms, as an immense treasure trove of natural products, have consistently been a
crucial source for researchers to explore and develop new natural products. Currently, the …

The emergence of antibiotic resistant pathogenic strains, especially Gram-negative bacteria,
has seriously increased in the last decades, endangering the efficiency of the antibiotics …

The relentless emergence of bacterial resistance to current antibiotics poses a significant
health treat, making the development of new effective treatments of vital importance. In this …

Microbial secondary metabolites are natural products that display various therapeutical or
agrochemical relevant activities (eg, antibiotics, antifungal, or antiproliferative agents …