A biomarker is a “characteristic that is measured as an indicator of normal biological
processes, pathogenic processes, or responses to an exposure or intervention, including …

Introduction: Although unmyelinated nerve fibers are affected in Charcot–Marie–Tooth type
1A (CMT1A) disease, they have not been studied in detail due to the invasive nature of the …

Aims To quantify the morphological alterations in corneal nerve fibres and cells in patients
with Type 2 diabetes mellitus in relation to the severity of diabetic retinopathy. Methods One …

Purpose: We investigated the relationship between corneal subbasal nerve (SBN) plexus
density, corneal sensitivity, and peripheral and cardiac autonomic neuropathy in patients …

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
neuronal loss, extracellular amyloid-β (Aβ) plaques, and intracellular neurofibrillary tau …

Purpose The present review highlights current concepts regarding the effects of diabetic
peripheral neuropathy (DPN) in skeletal muscle. It discusses the lack of effective …

Purpose.: In vivo corneal confocal microscopy (CCM) is increasingly used as a surrogate
endpoint in studies of diabetic polyneuropathy (DPN). However, it is not clear whether …

A proportion of people with fibromyalgia demonstrate small fibre pathology (SFP). However,
it is unclear how SFP directly relates to pain phenomenology. Thirty-three individuals with …

Dry eye disease (DED) has evolved into a major public health concern with ocular
discomfort and pain being responsible for significant morbidity associated with DED …

Accurate detection and quantification of human diabetic peripheral neuropathy are important
to define at-risk patients, anticipate deterioration, and assess new therapies. Easily …