The zoonotic emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected …

The ongoing SARS-CoV-2 pandemic has shocked the world due to its persistence, COVID-
19-related morbidity and mortality, and the high mutability of the virus. One of the major …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is closely related
to various cellular aspects associated with autophagy. However, how SARS-CoV-2 …

Positive single-strand RNA (+ RNA) viruses can remodel host cell membranes to induce a
replication organelle (RO) isolating the replication of their genome from innate immunity …

Viruses and their hosts have coevolved for a long time. This coevolution places both the
pathogen and the human immune system under selective pressure; on the one hand, the …

The severe acute respiratory syndrome associated coronavirus 2 (SARS-CoV-2) and SARS-
CoV-1 accessory protein Orf3a colocalizes with markers of the plasma membrane, endocytic …

Viroporins are indispensable for viral replication. As intracellular ion channels they disturb
pH gradients of organelles and allow Ca 2+ flux across ER membranes. Viroporins interact …

Background The recent emergence of COVID-19, rapid worldwide spread, and incomplete
knowledge of molecular mechanisms underlying SARS-CoV-2 infection have limited …

Highlights•Human coronaviruses use distinctand similar strategies to counteract innate
defenses.•Insights from SARS-CoV-2 will inspire research on endemic and epidemic …

The novel coronavirus, SARS-CoV-2, rapidly spread worldwide, causing an ongoing global
pandemic. While the respiratory system is the most common site of infection, a significant …