Mechanical damage is one of the predisposing factors of inflammation, and it runs through
the entire inflammatory pathological process. Repeated or persistent damaging mechanical …

Neuroinflammation is a critical factor in developing and progressing numerous brain
diseases, including neurodegenerative diseases. Chronic or excessive neuroinflammation …

Prion protein (PrP) aggregation and formation of PrP amyloid (APrP) are central events in
the pathogenesis of prion diseases. In the dominantly inherited prion protein amyloidosis …

In June 2021, the world was informed about a new drug for Alzheimer's disease approved
by the FDA. Aducanumab (BIIB037, ADU), being a monoclonal antibody IgG1, is the newest …

It has been illustrated that metabolic syndrome (MetS) is associated with Alzheimer disease
(AD) neuropathology. Components of MetS including central obesity, hypertension, insulin …

Most neurodegenerative diseases such as Alzheimer's disease, type 2 diabetes, Parkinson's
disease, etc. are caused by inclusions and plaques containing misfolded protein …

Hypothyroidism (HPT) HPT could be a risk factor for the development and progression of
Alzheimer's disease (AD). In addition, progressive neurodegeneration in AD may affect the …

Alzheimer's disease (AD) is the most common, age-dependent neurodegenerative disorder.
While AD has been intensively studied from different aspects, there is no effective cure for …

Alzheimer's Disease (AD) is characterized by the accumulation of extracellular amyloid-β
(Aβ) as well as CNS and systemic inflammation. Microglia, the myeloid cells resident in the …

Genetic, environmental, and aging-related insults can promote the misfolding and
subsequent aggregation of secreted proteins implicated in the pathogenesis of numerous …