JAK/STAT pathway: Extracellular signals, diseases, immunity, and therapeutic regimens

Q Hu, Q Bian, D Rong, L Wang, J Song… - … in Bioengineering and …, 2023 - frontiersin.org
Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were
originally thought to be intracellular signaling pathways that mediate cytokine signals in …

Exploring the JAK/STAT signaling pathway in hepatocellular carcinoma: unraveling signaling complexity and therapeutic implications

H Park, S Lee, J Lee, H Moon, SW Ro - International Journal of Molecular …, 2023 - mdpi.com
Hepatocellular Carcinoma (HCC) continues to pose a substantial global health challenge
due to its high incidence and limited therapeutic options. In recent years, the Janus Kinase …

Macrophage polarization and the regulation of bone immunity in bone homeostasis

K Hu, Z Shang, X Yang, Y Zhang… - Journal of Inflammation …, 2023 - Taylor & Francis
Bone homeostasis is a dynamic equilibrium state of bone formation and absorption,
ensuring skeletal development and repair. Bone immunity encompasses all aspects of the …

β-elemene alleviates hyperglycemia-induced cardiac inflammation and remodeling by inhibiting the JAK/STAT3-NF-κB pathway

J Wang, C Qian, Y Chen, T Jin, Y Jiang, L Huang, X Fu… - Phytomedicine, 2023 - Elsevier
Background Hyperglycemic induced cardiac hypertrophy and cardiac inflammation are
important pathological processes in diabetic cardiomyopathy. β-elemene (Ele) is a natural …

AMPK signaling inhibits the differentiation of myofibroblasts: Impact on age-related tissue fibrosis and degeneration

A Salminen - Biogerontology, 2024 - Springer
Disruption of the extracellular matrix (ECM) and an accumulation of fibrotic lesions within
tissues are two of the distinctive hallmarks of the aging process. Tissue fibroblasts are …

Pharmacological impact of microRNAs in head and neck squamous cell carcinoma: prevailing insights on molecular pathways, diagnosis, and nanomedicine …

B Bhattacharjee, AF Syeda, D Rynjah… - Frontiers in …, 2023 - frontiersin.org
Head and neck squamous cell carcinoma is a disease that most commonly produce tumours
from the lining of the epithelial cells of the lips, larynx, nasopharynx, mouth, or oro-pharynx. It …

The Phytochemical Agathisflavone Modulates miR146a and miR155 in Activated Microglia Involving STAT3 Signaling

BL Dos Santos, CC Dos Santos, KC da Silva… - International Journal of …, 2024 - mdpi.com
MicroRNAs (miRs) act as important post-transcriptional regulators of gene expression in
glial cells and have been shown to be involved in the pathogenesis of neurodegenerative …

Novel Janus Kinase Inhibitors in the Treatment of Dermatologic Conditions

I Ryguła, W Pikiewicz, K Kaminiów - Molecules, 2023 - mdpi.com
Janus kinase inhibitors, also known as JAK inhibitors, JAKinibs or JAKi, are a new group of
disease-modifying drugs. They work by inhibiting enzymes involved in the transmission of …

Ferulic acid protects against gamma-radiation induced liver injury via regulating JAK/STAT/Nrf2 pathways

RA Gawish, EM Samy, MM Aziz - Archives of Biochemistry and Biophysics, 2024 - Elsevier
This study aims to evaluate the effect and underlying mechanism of ferulic acid (FA) in
alleviating the acute liver injury by ionizing radiation (IR) in vivo. Rats were divided into …

Maladie rénale chronique et diabète de type 2. Histologie, pathogénie et stades évolutifs

L Monnier, S Halimi, C Colette - Médecine des Maladies Métaboliques, 2023 - Elsevier
Résumé «Néphropathie diabétique» ou «maladie rénale chronique du diabète de type 2»?
Telle est la question. Étant donné que la pathogénie de la maladie relève de multiples …