Prognostic and predictive biomarkers for immunotherapy in advanced renal cell carcinoma

M Rosellini, A Marchetti, V Mollica, A Rizzo… - Nature Reviews …, 2023 - nature.com
The therapeutic algorithm of renal cell carcinoma has been revolutionized by the approval of
immunotherapy agents by regulatory agencies. However, objective and durable responses …

[HTML][HTML] Tumorigenesis mechanisms found in hereditary renal cell carcinoma: a review

BR Webster, N Gopal, MW Ball - Genes, 2022 - mdpi.com
Renal cell carcinoma is a heterogenous cancer composed of an increasing number of
unique subtypes each with their own cellular and tumor behavior. The study of hereditary …

Belzutifan plus cabozantinib for patients with advanced clear cell renal cell carcinoma previously treated with immunotherapy: an open-label, single-arm, phase 2 …

TK Choueiri, DF McDermott, J Merchan… - The Lancet …, 2023 - thelancet.com
Background Few treatment options are available for patients with advanced renal cell
carcinoma who have received previous anti-PD-1-based or anti-PD-L1-based …

[HTML][HTML] Micropeptide MIAC inhibits the tumor progression by interacting with AQP2 and inhibiting EREG/EGFR signaling in renal cell carcinoma

M Li, G Liu, X Jin, H Guo, S Setrerrahmane, X Xu, T Li… - Molecular cancer, 2022 - Springer
Background Although, micropeptides encoded by non-coding RNA have been shown to
have an important role in a variety of tumors processes, there have been no reports on …

Health-related quality-of-life outcomes in patients with advanced renal cell carcinoma treated with lenvatinib plus pembrolizumab or everolimus versus sunitinib …

R Motzer, C Porta, B Alekseev, SY Rha… - The Lancet …, 2022 - thelancet.com
Background Results from the phase 3 CLEAR study showed that lenvatinib plus
pembrolizumab improved progression-free survival and overall survival compared with …

Pembrolizumab plus axitinib versus sunitinib as first-line treatment of advanced renal cell carcinoma: 43-month follow-up of the phase 3 KEYNOTE-426 study

ER Plimack, T Powles, V Stus, R Gafanov, D Nosov… - European Urology, 2023 - Elsevier
Previous analyses of KEYNOTE-426, an open-label, phase 3 randomized study, showed
superior efficacy of first-line pembrolizumab plus axitinib to sunitinib in advanced clear cell …

Comparative effectiveness of front-line ipilimumab and nivolumab or axitinib and pembrolizumab in metastatic clear cell renal cell carcinoma

KK Zarrabi, E Handorf, B Miron, MR Zibelman… - The …, 2023 - academic.oup.com
Background Treatment of metastatic renal cell carcinoma (mRCC) is rapidly evolving with
new combination therapies demonstrating improved response rates and survival. There are …

[HTML][HTML] The emerging role of PET/CT with PSMA-targeting radiopharmaceuticals in clear cell renal cancer: an updated systematic review

A Rizzo, M Racca, S Dall'Armellina, P Rescigno… - Cancers, 2023 - mdpi.com
Simple Summary Positron emission tomography/computed tomography (PET/CT) with
prostate-specific membrane antigen (PSMA)-targeting radiopharmaceuticals is a relatively …

[HTML][HTML] Multimodal recurrence scoring system for prediction of clear cell renal cell carcinoma outcome: a discovery and validation study

CP Gui, YH Chen, HW Zhao, JZ Cao, TJ Liu… - The Lancet Digital …, 2023 - thelancet.com
Background Improved markers for predicting recurrence are needed to stratify patients with
localised (stage I–III) renal cell carcinoma after surgery for selection of adjuvant therapy. We …

A multicenter comparative matched-pair analysis of percutaneous tumor ablation and robotic-assisted partial nephrectomy of T1b renal cell carcinoma (AblatT1b study …

G Cazalas, C Klein, G Piana, E De Kerviler, A Gangi… - European …, 2023 - Springer
Objective Renal cell carcinomas represent the sixth-and tenth-most frequently diagnosed
cancer in men and women. Recently, percutaneous-guided thermal ablations have proved …