Oligonucleotides (oligos) have been under clinical development for approximately the past
30 years, beginning with antisense oligonucleotides (ASOs) and apatmers and followed …

Hematopoietic stem-cell transplantation (hsct) is a medical procedure that consists of
infusing stem cells after a short course of chemotherapy or radiotherapy, or both. It can be …

Transfusion-dependent β-thalassemia (TDT) and sickle cell disease (SCD) are severe
monogenic diseases with severe and potentially life-threatening manifestations. BCL11A is …

Veno-occlusive disease, also known as sinusoidal obstruction syndrome (VOD/SOS), is a
potentially life-threatening complication of allogeneic or autologous hematopoietic stem cell …

Hepatic veno-occlusive disease (VOD) or sinusoidal obstruction syndrome (SOS) is a rare
complication characterized by hepatomegaly, right-upper quadrant pain, jaundice, and …

Summary Background The INO-VATE study demonstrated efficacy and safety of inotuzumab
ozogamicin versus standard care in adults with relapsed or refractory B-cell acute …

This study evaluated the safety, antitumor activity, pharmacokinetics, and
pharmacodynamics of inotuzumab ozogamicin (InO) for CD22-positive relapsed/refractory …

Inotuzumab ozogamicin (InO), a humanized anti-CD22 monoclonal antibody conjugated to
the cytotoxic antibiotic agent calicheamicin, has demonstrated efficacy in the phase 3 INO …

Sinusoidal obstruction syndrome (SOS), previously known as hepatic veno‐occlusive
disease (VOD), remains a multi‐organ system complication following haematopoietic cell …

Use of haematopoietic cell transplantation (HCT) in the treatment of haematologic and
neoplastic diseases may lead to life‐threatening complications that cause substantial …