[HTML][HTML] Origin, pathogenesis, diagnosis and treatment options for SARS-CoV-2: a review

H Sajjad, M Majeed, S Imtiaz, M Siddiqah, A Sajjad… - Biologia, 2021 - Springer
Emerging viral infections are among the greatest challenges in the public health sector in
the twenty-first century. Among these, most of the viruses jump from other species of animals …

Fully human immunoglobulin G from transchromosomic bovines treats nonhuman primates infected with Ebola virus Makona isolate

T Luke, RS Bennett, DM Gerhardt… - The Journal of …, 2018 - academic.oup.com
Transchromosomic bovines (Tc-bovines) adaptively produce fully human polyclonal
immunoglobulin (Ig) G antibodies after exposure to immunogenic antigen (s). The National …

Increased Antibody Avidity and Cross-Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Variants by Hyperimmunized Transchromosomic Bovine …

J Tang, G Grubbs, Y Lee, H Wu, TC Luke… - The Journal of …, 2022 - academic.oup.com
Passive antibody immunotherapeutics directed against severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) are promising countermeasures for protection and treatment of …

Use of Nanomaterials for Diagnosis and Treatment: The Advancement of Next-Generation Antiviral Therapy

D Mittal, SA Ali - Microbial Drug Resistance, 2022 - liebertpub.com
Globally, viral illness propagation is the leading cause of morbidity and death, causing
wreaking havoc on socioeconomic development and health care systems. The rise of …

Human monoclonal antibody derived from transchromosomic cattle neutralizes multiple H1 clades of influenza A virus by recognizing a novel conformational epitope …

R Gao, CC Sreenivasan, Z Sheng, BM Hause… - Journal of …, 2020 - Am Soc Microbiol
Influenza remains a global health risk and challenge. Currently, neuraminidase (NA)
inhibitors are extensively used to treat influenza, but their efficacy is compromised by the …

Potential role of hyperimmune milk as a source of passive immunotherapy against COVID-19: A review

P Singh, S Ghatak, P Kumar, N Mehta - International Dairy Journal, 2023 - Elsevier
COVID-19 is a devastating pandemic responsible for the current global health crisis.
Hyperimmune milk, produced after maternal immunisation of bovines, equines, camels …

SARS-CoV-2 neutralizing antibody development strategies

BK Balcioğlu, MDİİ ÖncÜ, HÜ Öztürk… - Turkish Journal of …, 2020 - journals.tubitak.gov.tr
In December 2019 a novel coronavirus was detected in Wuhan City of Hubei Province-
China. Owing to a high rate of transmission from human to human, the new virus called …

[HTML][HTML] Generation of a nebulizable CDR-modified MERS-CoV neutralizing human antibody

SI Kim, S Kim, J Kim, SY Chang, JM Shim, J Jin… - International Journal of …, 2019 - mdpi.com
Middle East respiratory syndrome coronavirus (MERS-CoV) induces severe aggravating
respiratory failure in infected patients, frequently resulting in mechanical ventilation. As …

[HTML][HTML] Development of medical countermeasures to Middle East respiratory syndrome coronavirus

TM Uyeki, KJ Erlandson, G Korch… - Emerging infectious …, 2016 - ncbi.nlm.nih.gov
Preclinical development of and research on potential Middle East respiratory syndrome
coronavirus (MERS-CoV) medical countermeasures remain preliminary; advancements are …

[HTML][HTML] Generation of H7N9-specific human polyclonal antibodies from a transchromosomic goat (caprine) system

H Wu, Z Fan, M Brandsrud, Q Meng, M Bobbitt… - Scientific Reports, 2019 - nature.com
To address the unmet needs for human polyclonal antibodies both as therapeutics and
diagnostic reagents, building upon our previously established transchromosomic (Tc) cattle …