There is extensive bi-directional communication between the brain and the immune system
in both health and disease. In recent years, the role of an altered immune system in the …

The current construct of schizophrenia as a unitary disease is far from satisfactory, and is in
need of reconceptualization. The first five papers in our “facts” series reviewed what is …

Background. Meta-analyses link childhood trauma to depression, mania, anxiety disorders,
and psychosis. It is unclear, however, whether these outcomes truly represent distinct …

Polycystic ovary syndrome (PCOS) is a highly complex endocrine disorder, characterized by
hyperandrogenemia, menstrual irregularities and polycystic ovaries. A strong genetic …

Importance More effective treatments are needed for negative symptoms of schizophrenia,
which are typically chronic, disabling, and costly. Negative symptoms have previously been …

Recent studies have provided robust evidence for an association between childhood trauma
(CT) and psychosis. Meta-analyses have quantified the association, pointing to odds ratios …

Metacognition reflects a spectrum of activities that includes discrete acts in which persons
form ideas about specific thoughts and feelings, and synthetic acts in which persons …

Objective: To investigate whether selected schizophrenia candidate single-nucleotide
polymorphisms (SNPs) moderate effects of cannabis use. Design: Interactions between …

There is much evidence that schizophrenia patients have an increased risk for aggression
and violent behavior, including homicide. The neurobiological basis and correlates of this …

Emerging researches point to a relevant role of postsynaptic density (PSD) proteins, such as
PSD-95, Homer, Shank, and DISC-1, in the pathophysiology of schizophrenia and autism …