Deep mutational learning predicts ACE2 binding and antibody escape to combinatorial mutations in the SARS-CoV-2 receptor-binding domain
The continual evolution of SARS-CoV-2 and the emergence of variants that show resistance
to vaccines and neutralizing antibodies threaten to prolong the COVID-19 pandemic …
to vaccines and neutralizing antibodies threaten to prolong the COVID-19 pandemic …
Evasion of neutralising antibodies by omicron sublineage BA. 2.75
DJ Sheward, C Kim, J Fischbach… - The Lancet Infectious …, 2022 - thelancet.com
Towards the end of 2021, SARS-CoV-2 vaccine effectiveness was threatened by the
emergence of the omicron clade (B. 1.1. 529), with more than 30 mutations in the spike …
emergence of the omicron clade (B. 1.1. 529), with more than 30 mutations in the spike …
Further humoral immunity evasion of emerging SARS-CoV-2 BA. 4 and BA. 5 subvariants
F Jian, Y Yu, W Song, A Yisimayi, L Yu… - The Lancet Infectious …, 2022 - thelancet.com
Multiple BA. 4 and BA. 5 subvariants with Arg346 mutations in the spike glycoprotein have
been identified in various countries, such as BA. 4.6, BF. 7, BA. 5.2. 6, BA. 4.1. 9, and BE. 1.2 …
been identified in various countries, such as BA. 4.6, BF. 7, BA. 5.2. 6, BA. 4.1. 9, and BE. 1.2 …
Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants
The persistent COVID-19 pandemic since 2020 has brought an enormous public health
burden to the global society and is accompanied by various evolution of the virus genome …
burden to the global society and is accompanied by various evolution of the virus genome …
SARS-CoV-2 Omicron sublineages exhibit distinct antibody escape patterns
H Gruell, K Vanshylla, M Korenkov, P Tober-Lau… - Cell Host & Microbe, 2022 - cell.com
SARS-CoV-2 neutralizing antibodies play a critical role in COVID-19 prevention and
treatment but are challenged by viral evolution and the emergence of novel escape variants …
treatment but are challenged by viral evolution and the emergence of novel escape variants …
A delicate balance between antibody evasion and ACE2 affinity for Omicron BA. 2.75
Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have caused
successive global waves of infection. These variants, with multiple mutations in the spike …
successive global waves of infection. These variants, with multiple mutations in the spike …
Origin, virological features, immune evasion and intervention of SARS-CoV-2 Omicron sublineages
Recently, a large number of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) variants continuously emerged and posed a major threat to global public health. Among …
2) variants continuously emerged and posed a major threat to global public health. Among …
Current status of therapeutic monoclonal antibodies against SARS-CoV-2
S Kumar, A Chandele, A Sharma - PLoS pathogens, 2021 - journals.plos.org
The ongoing Coronavirus Disease 2019 (COVID-19) pandemic has taken a toll on millions
of lives worldwide. Currently, India has the second highest number of active COVID-19 …
of lives worldwide. Currently, India has the second highest number of active COVID-19 …
An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion
SARS-CoV-2 Omicron subvariants have generated a worldwide health crisis due to
resistance to most approved SARS-CoV-2 neutralizing antibodies and evasion of …
resistance to most approved SARS-CoV-2 neutralizing antibodies and evasion of …
Potent pan huACE2-dependent sarbecovirus neutralizing monoclonal antibodies isolated from a BNT162b2-vaccinated SARS survivor
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
of concern such as Omicron hampered efforts in controlling the ongoing coronavirus disease …
of concern such as Omicron hampered efforts in controlling the ongoing coronavirus disease …