An inhaled ACE2 decoy confers protection against SARS-CoV-2 infection in preclinical models

E Urano, Y Itoh, T Suzuki, T Sasaki… - Science translational …, 2023 - science.org
The Omicron variant continuously evolves under the humoral immune pressure exerted by
vaccination and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …

A broad and potent neutralization epitope in SARS-related coronaviruses

M Yuan, X Zhu, W He, P Zhou… - Proceedings of the …, 2022 - National Acad Sciences
Many neutralizing antibodies (nAbs) elicited to ancestral severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) through natural infection and vaccination have reduced …

Potent pan huACE2-dependent sarbecovirus neutralizing monoclonal antibodies isolated from a BNT162b2-vaccinated SARS survivor

WN Chia, CW Tan, AWK Tan, B Young, TN Starr… - Science …, 2023 - science.org
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
of concern such as Omicron hampered efforts in controlling the ongoing coronavirus disease …

An overview on the treatments and prevention against COVID-19

Y Panahi, AM Gorabi, S Talaei, F Beiraghdar… - Virology Journal, 2023 - Springer
Background The coronavirus disease 2019 (COVID-19) caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to plague the world. While …

Convalescent plasma with a high level of virus-specific antibody effectively neutralizes SARS-CoV-2 variants of concern

M Li, EJ Beck, O Laeyendecker, Y Eby… - Blood …, 2022 - ashpublications.org
The ongoing evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants severely limits available effective monoclonal antibody therapies. Effective drugs …

Enhanced transmissibility of XBB. 1.5 is contributed by both strong ACE2 binding and antibody evasion

C Yue, W Song, L Wang, F Jian, X Chen, F Gao… - Biorxiv, 2023 - biorxiv.org
SARS-CoV-2 recombinant subvariant XBB. 1.5 is growing rapidly in the United States,
carrying an additional Ser486Pro substitution compared to XBB. 1 and outcompeting BQ. 1.1 …

Structural insights for neutralization of Omicron variants BA. 1, BA. 2, BA. 4, and BA. 5 by a broadly neutralizing SARS-CoV-2 antibody

S Kumar, A Patel, L Lai, C Chakravarthy… - Science …, 2022 - science.org
In this study, by characterizing several human monoclonal antibodies (mAbs) isolated from
single B cells of the COVID-19–recovered individuals in India who experienced ancestral …

SARS‐CoV‐2 Omicron and its current known unknowns: A narrative review

TTB Le, T Vasanthakumaran… - Reviews in medical …, 2023 - Wiley Online Library
The emergence of the SARS‐CoV‐2 Omicron variant (B. 1.1. 529) has created great global
distress. This variant of concern shows multiple sublineages, importantly B. 1.1. 529.1 (BA …

[HTML][HTML] Broadly neutralizing antibodies against COVID-19

D Zhou, J Ren, EE Fry, DI Stuart - Current Opinion in Virology, 2023 - Elsevier
The COVID-19 pandemic caused by SARS-CoV-2 has led to hundreds of millions of
infections and millions of deaths, however, human monoclonal antibodies (mAbs) can be an …

[PDF][PDF] Broad receptor tropism and immunogenicity of a clade 3 sarbecovirus

J Lee, SK Zepeda, YJ Park, AL Taylor, J Quispe… - Cell Host & Microbe, 2023 - cell.com
Although Rhinolophus bats harbor diverse clade 3 sarbecoviruses, the structural
determinants of receptor tropism along with the antigenicity of their spike (S) glycoproteins …