Neurological disorders have emerged as a predominant healthcare concern in recent years
due to their severe consequences on quality of life and prevalence throughout the world …

The heparan sulphate proteoglycan agrin is expressed as several isoforms in various
tissues. Agrin is best known as a crucial organizer of postsynaptic differentiation at the …

Proteoglycans are associated with all kinds of amyloid deposits in the human body. These
complex macromolecules, in particular heparan sulphate proteoglycans, have also been …

Proteoglycans located in basement membranes, the nanostructures underling epithelial and
endothelial layers, are unique in several respects. They are usually large, elongated …

Accumulation of amyloid-β (Aβ) peptide in the brain is the first critical step in the
pathogenesis of Alzheimer's disease (AD). Studies in humans suggest that Aβ clearance …

RPTPσ is a cell adhesion molecule-like receptor protein tyrosine phosphatase involved in
nervous system development. Its avian orthologue, known as cPTPσ or CRYPα, promotes …

Alzheimer disease and cerebrovascular dementia are two common causes of dementia and,
by present diagnostic criteria, are mutually exclusive using vascular pathology as an …

The quality of the blood-brain barrier (BBB), represented mainly by endothelial tight
junctions (TJ), is now believed to be dependent on the brain microenvironment and …

α-Synuclein is an abundant presynaptic brain protein, misfolding, aggregation and
fibrillation of which are implicated as critical factors in several neurodegenerative diseases …

Mental actions are based on the dynamic organization of neuronal networks. In particular,
phylogenetically young brain areas (eg, cortical associative circuits) involved in the …