Mental function has as its cerebral basis a specific dynamic structure. In particular, cortical
and limbic areas involved in “higher brain functions” such as learning, memory, perception …

Heparan sulfate proteoglycans (HSPGs) are ubiquitously present within the perivascular
basement membrane, and have been shown to be altered in patients with Alzheimer's …

This review is focused on the structure and function of Alzheimer's amyloid deposits.
Amyloid formation is a process in which normal well-folded cellular proteins undergo a self …

Agrin is an extracellular matrix heparan sulfate proteoglycan (HSPG) well known for its role
in modulation of the neuromuscular junction during development. Although agrin is one of …

The extracellular accumulation of amyloid β proteins (Aβs) in neuritic plaques is one of the
hallmarks of Alzheimer's disease (AD). The binding of Aβs to extracellular membranes …

The dense neuropil of the central nervous system leaves only limited space for extracellular
substances free. The advent of immunohistochemistry, soon followed by advanced …

Heparan sulfate proteoglycans (HSPGs) have been suggested to play an important role in
the formation and persistence of senile plaques and neurofibrillary tangles in dementia of …

A characteristic feature of Alzheimer's disease (AD) is the formation of amyloid plaques in
the brain. Although this hallmark pathology has been well described, the biological effects of …

The pathologic lesions of Alzheimer's disease (AD) are characterized by accumulation of
protein aggregates consisting of intracellular or extracellular misfolded proteins. The …

Tauopathies are a class of neurodegenerative diseases, including Alzheimer's disease, and
are characterized by intraneuronal tau inclusion in the brain and the patient's cognitive …