The brain is a highly vascularized tissue protected by the blood–brain barrier (BBB), a
complex structure allowing only necessary substances to pass through into the brain while …

Amyloid‐related diseases are often ascribed to protein “misfolding.” Yet in the absence of
high‐resolution structures for mature fibrils or intermediates, the connection between the …

The extracellular matrix (ECM) is a substrate upon which cells migrate, proliferate and
differentiate. It is involved in the maintenance of cytoarchitecture, regulation of homeostasis …

Alzheimer's disease (AD) is the most common form of dementia, characterized by
progressive loss of memory and cognitive dysfunctions. A central pathological event of AD is …

Alzheimer's disease (AD) is the most common form of dementia. Currently, there is no
effective treatment for AD, as its etiology remains poorly understood. Mounting evidence …

APOE4 homozygosity has been associated with an increased risk of sporadic Alzheimer's
disease through a mechanism, which has yet to be defined. Recent evidence has suggested …

Cerebrovascular deposition of amyloid β protein (Aβ) is a characteristic lesion of Alzheimer's
disease (AD) and hereditary cerebral hemorrhage with amyloidosis of the Dutch type …

There is increasing evidence for blood-brain barrier (BBB) compromise in Alzheimer
disease (AD). The presence of the ɛ4 allele of the apolipoprotein E (apoE) gene is a risk …

Alzheimer's disease (AD) and cerebrovascular dementia (CVD) are two major causes of
senile dementia in elderly individuals. Mounting evidence from epidemiological, clinical, and …

Factor H, a regulatory protein of the alternative pathway of complement (APC), is present in
amyloid-β (Aβ) plaques in Alzheimer's disease (AD). Aβ plaques also contain significant …