The role of blood-cerebrospinal fluid barrier (BCB) dysfunction in Alzheimer's disease (AD)
has been addressed but not yet established. We evaluated the BCB integrity in 179 samples …

The behavior of the proteome reflects spatial and temporal organization both within and
without cells. We propose that various macromolecular entities possessing polyanionic …

Microtubule-associated protein tau (MAPT) hyperphosphorylation and aggregation, are two
hallmarks of a family of neurodegenerative disorders collectively referred to as tauopathies …

Dendritic spines are dynamic structures that accommodate the majority of excitatory
synapses in the brain and are influenced by extracellular signals from presynaptic neurons …

Previous studies have suggested that heparan sulfate proteoglycans (HSPGs) play a role in
deposition of β‐amyloid protein (Aβ) in the Alzheimer's disease (AD) brain. In the present …

Background Exposure to benzo (a) pyrene (BaP) was associated with cognitive impairments
and some Alzheimer's disease (AD)-like pathological changes. However, it is largely …

Recent findings showed that vascular dysfunction is an integral part of Alzheimer's disease
pathology. Increased microvascular permeability is mainly associated with cerebrovascular …

Recent studies have begun to investigate the role of agrin in brain and suggest that agrin's
function likely extends beyond that of a synaptogenic protein. Particularly, it has been shown …

Conditions that compromise the blood-brain barrier (BBB) have been increasingly
implicated in the pathogenesis of Alzheimer disease (AD). AGRIN is a heparan sulfate …

Alzheimer's disease (AD) brains are characterized by the presence of senile plaques (SPs),
which primarily consist of amyloid β protein (Aβ). Besides Aβ, several other proteins with the …