In the past, the blood-brain barrier (BBB) has been characterized mainly as a layer of
endothelial cells forming the vessel/capillary wall of the brain. More recently, the BBB is …

Alzheimer's disease (AD) is characterized by extracellular cerebral accumulation of amyloid
β peptide (Aβ). Heparan sulfate (HS) is a glycosaminoglycan that is abundant in the …

To identify some apparent biomarker candidates for the diagnosis of Alzheimer's disease
(AD) pathology, we investigated whether there would be a significant difference between the …

Nifedipine, a calcium channel blocker, has been reported to exert pleiotropic effects on
atherosclerosis, mainly through its antioxidative properties. However, the effect of the …

The neuregulins are a family of polypeptide factors implicated in a wide range of
neurological and psychiatric disorders including multiple sclerosis, schizophrenia, and …

With recent advances in the construction of synthetic glycans, selective targeting of the
extracellular matrix (ECM) as a potential treatment for a wide range of diseases has become …

Matrix metalloproteinases are important regulators of extracellular matrix molecules and cell-
cell signaling. Antibodies to matrix metalloproteinase 3 (MMP3) recognize molecules at the …

Neurodegenerative diseases (NDDs) affect more than 50 million people worldwide, posing
a significant global health challenge as well as a high socioeconomic burden. With aging …

Heparan sulfate proteoglycans mediate cell adhesion and control the activities of numerous
growth and motility factors. They play a critical role in carcinogenesis and tumor progression …

Amyloidosis is a generic term for a group of diseases characterized by deposits in different
organ systems of insoluble materials composed mainly of distinct fibrillar proteins named …