Neural extracellular matrix (ECM) is different from the normal ECM in other organs in that it
has low fibrous protein content and high carbohydrate content. One of the key carbohydrate …

Biochemical characterization of the major detergent‐insoluble proteins that comprise
hallmark histopathologic lesions initiated the molecular era of Alzheimer's disease (AD) …

Objective This study aimed to identify the potential urine biomarkers of vascular dementia
(VD) and unravel the disease-associated mechanisms by applying Liquid chromatography …

Introduction: Proline/arginine-rich end leucine-rich repeat protein (PRELP), is a small
secreted proteoglycan expressed by pericytes and vascular smooth muscle cells …

The goals of this work were i) to identify the interactions of amyloid-β (Aβ) 42 under
monomeric, oligomeric, and fibrillar forms with the extracellular matrix (ECM) and receptors …

Aging is defined as a progressive decline of cognitive and physiological functions over
lifetime. Since the definition of the nine hallmarks of aging in 2013 by López-Otin, numerous …

Amyloidosis refers to a group of diseases characterized by abnormal deposition of
denatured endogenous proteins, termed amyloid, in the affected organs. Analysis of biopsy …

The extracellular matrix molecule agrin mediates the motor neuron induced accumulation of
acetylcholine receptors (AChR) at the neuromuscular junction. Agrin is also present in the …

Alzheimer's disease is a neurodegenerative disease in which aging is not only a major risk
factor but a major determinant of onset, course, and pathogenesis. The synthesis of amyloid …

Agrin mediates motor neuron-induced differentiation of the postsynaptic apparatus of the
neuromuscular junction but its function in brain remains unknown. Here we report that …