During the last forty years we have witnessed impressive advances in the field of antiviral
drug discovery culminating with the introduction of therapies able to stop human …

SARS-CoV-2 belongs to the family of enveloped, single-strand RNA viruses known as
Betacoronavirus in Coronaviridae, first reported late 2019 in China. It has since been …

Antiviral drugs have traditionally been developed by directly targeting essential viral
components. However, this strategy often fails due to the rapid generation of drug-resistant …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is already responsible for
far more deaths than previous pathogenic coronaviruses (CoVs) from 2002 and 2012. The …

Treating a viral disease is no simple feat. Drug resistance, latent reservoirs in the body,
emerging novel viruses, and a frequent lack of specific treatments all complicate antiviral …

This is the second of two invited articles reviewing the development of nucleoside analogue
antiviral drugs, written for a target audience of virologists and other non-chemists, as well as …

The ProTide technology is a prodrug approach developed for the efficient intracellular
delivery of nucleoside analogue monophosphates and monophosphonates. In this …

COVID-19 has now been declared a pandemic and new treatments are urgently needed as
we enter a phase beyond containment. Developing new drugs from scratch is a lengthy …

Lignin is a major phenolic polymer from the plant biomass. Due to its abundant functional
groups (carboxyl and hydroxyl groups), lignin could act as an antioxidant, antimicrobial as …

The environmental release of antiviral drugs is of considerable concern due to potential
ecosystem alterations and the development of antiviral resistance. As a result, interest on …