Targeting nucleotide metabolism as the nexus of viral infections, cancer, and the immune response
Virus-infected cells and cancers share metabolic commonalities that stem from their
insatiable need to replicate while evading the host immune system. These similarities …
insatiable need to replicate while evading the host immune system. These similarities …
Nitric oxide to fight viral infections
Abstract Coronavirus disease 2019 (COVID‐19) is an infectious disease caused by the
severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) that has quickly and …
severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) that has quickly and …
[HTML][HTML] Lycorine, a non-nucleoside RNA dependent RNA polymerase inhibitor, as potential treatment for emerging coronavirus infections
Background: Highly effective novel treatments need to be developed to suppress emerging
coronavirus (CoV) infections such as COVID-19. The RNA dependent RNA polymerase …
coronavirus (CoV) infections such as COVID-19. The RNA dependent RNA polymerase …
A painful lesson from the COVID-19 pandemic: the need for broad-spectrum, host-directed antivirals
VC Chitalia, AH Munawar - Journal of translational medicine, 2020 - Springer
While the COVID-19 pandemic has spurred intense research and collaborative discovery
worldwide, the development of a safe, effective, and targeted antiviral from the ground up is …
worldwide, the development of a safe, effective, and targeted antiviral from the ground up is …
[PDF][PDF] Detect and destroy: CRISPR-based technologies for the response against viruses
CA Freije, PC Sabeti - Cell host & microbe, 2021 - cell.com
Despite numerous viral outbreaks in the last decade, including a devastating global
pandemic, diagnostic and therapeutic technologies remain severely lacking. CRISPR-Cas …
pandemic, diagnostic and therapeutic technologies remain severely lacking. CRISPR-Cas …
Pathogenesis‐directed therapy of 2019 novel coronavirus disease
CW Stratton, YW Tang, H Lu - Journal of medical virology, 2021 - Wiley Online Library
The 2019 novel coronavirus disease (COVID‐19) now is considered a global public health
emergency. One of the unprecedented challenges is defining the optimal therapy for those …
emergency. One of the unprecedented challenges is defining the optimal therapy for those …
Identifying the natural polyphenol catechin as a multi-targeted agent against SARS-CoV-2 for the plausible therapy of COVID-19: an integrated computational …
The global pandemic crisis, coronavirus disease 2019 (COVID-19), caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has claimed the lives of millions of …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has claimed the lives of millions of …
Sofosbuvir terminated RNA is more resistant to SARS-CoV-2 proofreader than RNA terminated by Remdesivir
S Jockusch, C Tao, X Li, M Chien, S Kumar… - Scientific reports, 2020 - nature.com
SARS-CoV-2 is responsible for COVID-19, resulting in the largest pandemic in over a
hundred years. After examining the molecular structures and activities of hepatitis C viral …
hundred years. After examining the molecular structures and activities of hepatitis C viral …
40 years after the registration of acyclovir: do we need new anti-herpetic drugs?
A Majewska, B Mlynarczyk-Bonikowska - International journal of …, 2022 - mdpi.com
Herpes simplex virus types 1 and 2 HSV1 and 2, namely varicella-zoster VZV and
cytomegalovirus CMV, are among the most common pathogens worldwide. They remain in …
cytomegalovirus CMV, are among the most common pathogens worldwide. They remain in …
Current therapy for chronic hepatitis C: The role of direct-acting antivirals
G Li, E De Clercq - Antiviral research, 2017 - Elsevier
One of the most exciting developments in antiviral research has been the discovery of the
direct-acting antivirals (DAAs) that effectively cure chronic hepatitis C virus (HCV) infections …
direct-acting antivirals (DAAs) that effectively cure chronic hepatitis C virus (HCV) infections …