Fifty years of research on schizophrenia: the ascendance of the glutamatergic synapse
In 1976, I (JTC) finished my psychiatric residency, received my first National Institutes of
Health grant, opened my laboratory, and took responsibility for the Schizophrenia Outpatient …
Health grant, opened my laboratory, and took responsibility for the Schizophrenia Outpatient …
Extensive bidirectional genetic overlap between bipolar disorder and cardiovascular disease phenotypes
Patients with bipolar disorder (BIP) have a high risk of cardiovascular disease (CVD),
despite considerable individual variation. The mechanisms underlying comorbid CVD in BIP …
despite considerable individual variation. The mechanisms underlying comorbid CVD in BIP …
Crosstalk between schizophrenia and metabolic syndrome: The role of oxytocinergic dysfunction
KK Goh, CYA Chen, TH Wu, CH Chen… - International journal of …, 2022 - mdpi.com
The high prevalence of metabolic syndrome in persons with schizophrenia has spurred
investigational efforts to study the mechanism beneath its pathophysiology. Early psychosis …
investigational efforts to study the mechanism beneath its pathophysiology. Early psychosis …
Hydrogen sulfide and polysulfides induce GABA/glutamate/d-serine release, facilitate hippocampal LTP, and regulate behavioral hyperactivity
H Furuie, Y Kimura, T Akaishi, M Yamada… - Scientific reports, 2023 - nature.com
Hydrogen sulfide (H2S) and polysulfides (H2Sn, n≥ 2) are signaling molecules produced
by 3-mercaptopyruvate sulfurtransferase (3MST) that play various physiological roles …
by 3-mercaptopyruvate sulfurtransferase (3MST) that play various physiological roles …
Genome-wide association study of over 40,000 bipolar disorder cases provides novel biological insights
Bipolar disorder (BD) is a heritable mental illness with complex etiology. We performed a
genome-wide association study (GWAS) of 41,917 BD cases and 371,549 controls of …
genome-wide association study (GWAS) of 41,917 BD cases and 371,549 controls of …
[HTML][HTML] The thalamus in psychosis spectrum disorder
A Anticevic, MM Halassa - Frontiers in Neuroscience, 2023 - frontiersin.org
Psychosis spectrum disorder (PSD) affects 1% of the world population and results in a
lifetime of chronic disability, causing devastating personal and economic consequences …
lifetime of chronic disability, causing devastating personal and economic consequences …
[HTML][HTML] Shared genetic loci between Alzheimer's disease and multiple sclerosis: Crossroads between neurodegeneration and immune system
V Fominykh, AA Shadrin, PP Jaholkowski… - Neurobiology of …, 2023 - Elsevier
Background Neuroinflammation is involved in the pathophysiology of Alzheimer's disease
(AD), including immune-linked genetic variants and molecular pathways, microglia and …
(AD), including immune-linked genetic variants and molecular pathways, microglia and …
Progressive trajectories of schizophrenia across symptoms, genes, and the brain
Background Schizophrenia is characterized by complex psychiatric symptoms and unclear
pathological mechanisms. Most previous studies have focused on the morphological …
pathological mechanisms. Most previous studies have focused on the morphological …
Regulation of reactive oxygen species-mediated damage in the pathogenesis of schizophrenia
S Madireddy, S Madireddy - Brain Sciences, 2020 - mdpi.com
The biochemical integrity of the brain is paramount to the function of the central nervous
system, and oxidative stress is a key contributor to cerebral biochemical impairment …
system, and oxidative stress is a key contributor to cerebral biochemical impairment …
Characterising the shared genetic determinants of bipolar disorder, schizophrenia and risk-taking
Increased risk-taking is a central component of bipolar disorder (BIP) and is implicated in
schizophrenia (SCZ). Risky behaviours, including smoking and alcohol use, are …
schizophrenia (SCZ). Risky behaviours, including smoking and alcohol use, are …