[HTML][HTML] Immune marker levels in severe mental disorders: associations with polygenic risk scores of related mental phenotypes and psoriasis
MCF Werner, KV Wirgenes, A Shadrin… - Translational …, 2022 - nature.com
Several lines of evidence implicate immune abnormalities in the pathophysiology of severe
mental disorders (SMD) and comorbid mental disorders. Here, we use the data from …
mental disorders (SMD) and comorbid mental disorders. Here, we use the data from …
[HTML][HTML] Elevated endogenous GDNF induces altered dopamine signalling in mice and correlates with clinical severity in schizophrenia
K Mätlik, DR Garton, AR Montaño-Rodríguez… - Molecular …, 2022 - nature.com
Presynaptic increase in striatal dopamine is the primary dopaminergic abnormality in
schizophrenia, but the underlying mechanisms are not understood. Here, we hypothesized …
schizophrenia, but the underlying mechanisms are not understood. Here, we hypothesized …
[HTML][HTML] The genetic relationships between brain structure and schizophrenia
Genetic risks for schizophrenia are theoretically mediated by genetic effects on brain
structure but it has been unclear which genes are associated with both schizophrenia and …
structure but it has been unclear which genes are associated with both schizophrenia and …
Psychiatric disorders and brain white matter exhibit genetic overlap implicating developmental and neural cell biology
Improved understanding of the shared genetic architecture between psychiatric disorders
and brain white matter may provide mechanistic insights for observed phenotypic …
and brain white matter may provide mechanistic insights for observed phenotypic …
[HTML][HTML] Single-nucleus RNA sequencing of midbrain blood-brain barrier cells in schizophrenia reveals subtle transcriptional changes with overall preservation of …
S Puvogel, A Alsema, L Kracht, MJ Webster… - Molecular …, 2022 - nature.com
The midbrain is an extensively studied brain region in schizophrenia, in view of its reported
dopamine pathophysiology and neuroimmune changes associated with this disease …
dopamine pathophysiology and neuroimmune changes associated with this disease …
Shared genetic loci between schizophrenia and white blood cell counts suggest genetically determined systemic immune abnormalities
Background Immune mechanisms are indicated in schizophrenia (SCZ). Recent genome-
wide association studies (GWAS) have identified genetic variants associated with SCZ and …
wide association studies (GWAS) have identified genetic variants associated with SCZ and …
Charting the landscape of genetic overlap between mental disorders and related traits beyond genetic correlation
Objective: Mental disorders are heritable and polygenic, and genome-wide genetic
correlations (rg) have indicated widespread shared genetic risk across multiple disorders …
correlations (rg) have indicated widespread shared genetic risk across multiple disorders …
[HTML][HTML] Improving knowledge on pathways to functional outcome in schizophrenia: main results from the Italian network for research on psychoses
L Giuliani, GM Giordano, P Bucci, P Pezzella… - Frontiers in …, 2021 - frontiersin.org
The identification of factors associated with functional outcome of subjects with
schizophrenia is a great challenge in current research oriented to the personalization of …
schizophrenia is a great challenge in current research oriented to the personalization of …
[HTML][HTML] Predicting treatment response in schizophrenia with magnetic resonance imaging and polygenic risk score
Background: Prior studies have separately demonstrated that magnetic resonance imaging
(MRI) and schizophrenia polygenic risk score (PRS) are predictive of antipsychotic …
(MRI) and schizophrenia polygenic risk score (PRS) are predictive of antipsychotic …
Revisiting tandem repeats in psychiatric disorders from perspectives of genetics, physiology, and brain evolution
Genome-wide association studies (GWASs) have revealed substantial genetic components
comprised of single nucleotide polymorphisms (SNPs) in the heritable risk of psychiatric …
comprised of single nucleotide polymorphisms (SNPs) in the heritable risk of psychiatric …