The shared genetic basis of mood instability and psychiatric disorders: A cross‐trait genome‐wide association analysis

G Hindley, KS O'Connell, Z Rahman… - American Journal of …, 2022 - Wiley Online Library
Recent genome‐wide association studies of mood instability (MOOD) have found significant
positive genetic correlation with major depression (DEP) and weak correlations with other …

Genome‐wide analysis reveals genetic overlap between alcohol use behaviours, schizophrenia and bipolar disorder and identifies novel shared risk loci

ED Wiström, KS O'Connell, N Karadag, S Bahrami… - …, 2022 - Wiley Online Library
Background and aim Schizophrenia (SCZ) and bipolar disorder (BD) have a high
comorbidity of alcohol use disorder (AUD), and both comorbid AUD and excessive alcohol …

Microglia and cognitive impairment in schizophrenia: translating scientific progress into novel therapeutic interventions

C Zhuo, H Tian, X Song, D Jiang, G Chen, Z Cai… - Schizophrenia, 2023 - nature.com
Cognitive impairment is a core clinical feature of schizophrenia, exerting profound adverse
effects on social functioning and quality of life in a large proportion of patients with …

Quantifying the polygenic architecture of the human cerebral cortex: Extensive genetic overlap between cortical thickness and surface area

D van der Meer, O Frei, T Kaufmann, CH Chen… - Cerebral …, 2020 - academic.oup.com
The thickness of the cerebral cortical sheet and its surface area are highly heritable traits
thought to have largely distinct polygenic architectures. Despite large-scale efforts, the …

Pro/antioxidant state as a potential biomarker of schizophrenia

D Juchnowicz, M Dzikowski, J Rog… - Journal of Clinical …, 2021 - mdpi.com
To allow better diagnosis and management of psychiatric illnesses, the use of easily
accessible biomarkers are proposed. Therefore, recognition of some diseases by a set of …

Genome-wide Association Analysis of Schizophrenia and Vitamin D Levels Shows Shared Genetic Architecture and Identifies Novel Risk Loci

P Jaholkowski, GFL Hindley, AA Shadrin… - Schizophrenia …, 2023 - academic.oup.com
Low vitamin D (vitD) levels have been consistently reported in schizophrenia (SCZ)
suggesting a role in the etiopathology. However, little is known about the role of underlying …

Shared genetic architecture between neuroticism, coronary artery disease and cardiovascular risk factors

K Torgersen, S Bahrami, O Frei, A Shadrin… - Translational …, 2021 - nature.com
Neuroticism is associated with poor health, cardiovascular disease (CVD) risk factors and
coronary artery disease (CAD). The conditional/conjunctional false discovery rate method …

The schizophrenia syndrome, circa 2024: What we know and how that informs its nature

R Tandon, H Nasrallah, S Akbarian… - Schizophrenia …, 2024 - Elsevier
With new data about different aspects of schizophrenia being continually generated, it
becomes necessary to periodically revisit exactly what we know. Along with a need to review …

[PDF][PDF] Novel ultra-rare exonic variants identified in a founder population implicate cadherins in schizophrenia

T Lencz, J Yu, RR Khan, E Flaherty, S Carmi, M Lam… - Neuron, 2021 - cell.com
The identification of rare variants associated with schizophrenia has proven challenging due
to genetic heterogeneity, which is reduced in founder populations. In samples from the …

Brain vasculature disturbance in schizophrenia

S Puvogel, V Palma, IEC Sommer - Current opinion in psychiatry, 2022 - journals.lww.com
In some patients with SZ, a vulnerable brain endothelium may be interacting with
environmental stressors, such as inflammation or hypoxia, converging into a more severe SZ …