Mitochondria-associated endoplasmic reticulum membrane (MAM): a dark horse for diabetic cardiomyopathy treatment

Y Liu, JL Huo, K Ren, S Pan, H Liu, Y Zheng… - Cell Death …, 2024 - nature.com
Diabetic cardiomyopathy (DCM), an important complication of diabetes mellitus (DM), is one
of the most serious chronic heart diseases and has become a major cause of heart failure …

Inhibition of the pyroptosis-associated inflammasome pathway: The important potential mechanism of ginsenosides in ameliorating diabetes and its complications

P Liu, Z Zhang, Y Cai, Y Yang, J Yuan… - European Journal of …, 2023 - Elsevier
Diabetes mellitus (DM) and its complications have become an important global public health
issue, affecting human health and negatively impacting life and lifespan. Pyroptosis is a …

[PDF][PDF] NLRP3 炎性小体在慢性心力衰竭中的作用与机制

王敢, 钟江华 - 临床心血管病杂志, 2023 - en.whuhzzs.com
慢性心力衰竭(chronicheartfailure, CHF) 是各类心血管疾病的终末期阶段. CHF
的治疗方案近年虽不断完善, 但仍有较高的死亡率与住院率, 给患者及家庭带来了巨大的医疗 …

Role of pyroptosis in diabetic cardiomyopathy: an updated review

G Wang, TY Ma, K Huang, JH Zhong, SJ Lu… - Frontiers in …, 2024 - frontiersin.org
Diabetic cardiomyopathy (DCM), one of the common complications of diabetes, presents as
a specific cardiomyopathy with anomalies in the structure and function of the heart. With the …

Implications and hidden toxicity of cardiometabolic syndrome and early‐stage heart failure in carfilzomib‐induced cardiotoxicity

P Efentakis, A Varela, S Lamprou… - British Journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose Cancer therapy‐related cardiovascular adverse events
(CAEs) in presence of comorbidities, are in the spotlight of the cardio‐oncology guidelines …

Metabolic remodelling in atrial fibrillation: manifestations, mechanisms and clinical implications

D Bode, JRD Pronto, GG Schiattarella… - Nature Reviews …, 2024 - nature.com
Atrial fibrillation (AF) is a continually growing health-care burden that often presents together
with metabolic disorders, including diabetes mellitus and obesity. Current treatments often …

Puerarin mitigated LPS‐ATP or HG‐primed endothelial cells damage and diabetes‐associated cardiovascular disease via ROS‐NLRP3 signalling

H Wei, M Sun, R Wang, H Zeng… - Journal of Cellular and …, 2024 - Wiley Online Library
The occurrence and development of diabetic vascular diseases are closely linked to
inflammation‐induced endothelial dysfunction. Puerarin (Pue), the primary component of …

Diabetic Cardiomyopathy—From Basics through Diagnosis to Treatment

E Radzioch, B Dąbek, M Balcerczyk-Lis, W Frąk… - Biomedicines, 2024 - mdpi.com
Diabetic cardiomyopathy (DCM) is the development of myocardial dysfunction in patients
with diabetes despite the absence of comorbidities such as hypertension, atherosclerosis or …

Cannabinoid 2 receptor activation protects against diabetic cardiomyopathy through inhibition of AGE/RAGE-induced oxidative stress, fibrosis, and inflammasome …

HM Hashiesh, S Azimullah, NM MF… - Journal of …, 2024 - jpet.aspetjournals.org
Oxidative stress, fibrosis, and inflammasome activation from AGE-RAGE interaction
contribute to diabetic cardiomyopathy (DCM) formation and progression. Our study revealed …

Ginsenoside Rb1 reduces oxidative/carbonyl stress damage and dysfunction of RyR2 in the heart of streptozotocin-induced diabetic rats

C Feng, J Song, L Deng, J Zhang, X Lian… - BMC Cardiovascular …, 2024 - Springer
Background Oxidative stress may contribute to cardiac ryanodine receptor (RyR2)
dysfunction in diabetic cardiomyopathy. Ginsenoside Rb1 (Rb1) is a major …