Progressive loss of physiological integrity and accumulation of degenerative changes
leading to functional impairment and increased susceptibility to diseases are the main …

Advanced age is a primary risk factor for female infertility due to reduced ovarian reserve
and declining oocyte quality. However, as an important contributing factor, the role of …

The decline in fertility in aging women, especially those with poor ovarian response (POR)
or primary ovarian insufficiency (POI), is a major concern for modern IVF centers. Fertility …

Abnormal resumption of meiosis and decreased oocyte quality are hallmarks of maternal
aging. Transcriptional silencing makes translational control an urgent task during meiosis …

The oocyte is considered to be the largest cell in mammalian species. Women hoping to
become pregnant face a ticking biological clock. This is becoming increasingly challenging …

Objective: Adverse pregnancy outcomes are closely related to advanced maternal age
(AMA; age at pregnancy≥ 35 years). Little research has been reported on aneuploid …

Preimplantation genetic testing for aneuploidy (PGT-A) is widespread, but controversial, in
humans and improves pregnancy and live birth rates in cattle. In pigs, it presents a possible …

The aim of this review is to discuss how aneuploidy contributes to the aging process, and to
identify plausible strategies for its prevention. After an overview of mechanisms leading to …

Background With advanced maternal age, abnormalities during oocyte meiosis increase
significantly. Aneuploidy is an important reason for the reduction in the quality of aged …

It has been reported that environmental factors, such as industrial pollution, environmental
toxins, environmental hormones, and global warming contribute to the oxidative stress …