RASA2 ablation in T cells boosts antigen sensitivity and long-term function
The efficacy of adoptive T cell therapies for cancer treatment can be limited by suppressive
signals from both extrinsic factors and intrinsic inhibitory checkpoints,. Targeted gene editing …
signals from both extrinsic factors and intrinsic inhibitory checkpoints,. Targeted gene editing …
CD8+ T cell differentiation and dysfunction in cancer
M Philip, A Schietinger - Nature Reviews Immunology, 2022 - nature.com
CD8+ T cells specific for cancer cells are detected within tumours. However, despite their
presence, tumours progress. The clinical success of immune checkpoint blockade and …
presence, tumours progress. The clinical success of immune checkpoint blockade and …
Nanomaterials in tumor immunotherapy: new strategies and challenges
X Zhu, S Li - Molecular Cancer, 2023 - Springer
Tumor immunotherapy exerts its anti-tumor effects by stimulating and enhancing immune
responses of the body. It has become another important modality of anti-tumor therapy with …
responses of the body. It has become another important modality of anti-tumor therapy with …
Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen
The majority of tumor-infiltrating T cells exhibit a terminally exhausted phenotype, marked by
a loss of self-renewal capacity. How repetitive antigenic stimulation impairs T cell self …
a loss of self-renewal capacity. How repetitive antigenic stimulation impairs T cell self …
[HTML][HTML] Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer
T cell exhaustion is a major impediment to antitumor immunity. However, it remains elusive
how other immune cells in the tumor microenvironment (TME) contribute to this dysfunctional …
how other immune cells in the tumor microenvironment (TME) contribute to this dysfunctional …
TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion
Abstract Exhausted CD8+ T (Tex) cells in chronic infections and cancer have limited effector
function, high co-expression of inhibitory receptors and extensive transcriptional changes …
function, high co-expression of inhibitory receptors and extensive transcriptional changes …
The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy
Checkpoint inhibitor-based immunotherapies that target cytotoxic T lymphocyte antigen 4
(CTLA4) or the programmed cell death 1 (PD1) pathway have achieved impressive success …
(CTLA4) or the programmed cell death 1 (PD1) pathway have achieved impressive success …
Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade
T cell dysfunction is a hallmark of many cancers, but the basis for T cell dysfunction and the
mechanisms by which antibody blockade of the inhibitory receptor PD-1 (anti-PD-1) …
mechanisms by which antibody blockade of the inhibitory receptor PD-1 (anti-PD-1) …
Resistance mechanisms of anti-PD1/PDL1 therapy in solid tumors
Q Lei, D Wang, K Sun, L Wang… - Frontiers in cell and …, 2020 - frontiersin.org
In cancer-immunity cycle, the immune checkpoint PD1 and its ligand PDL1 act as
accomplices to help tumors resist to immunity-induced apoptosis and promote tumor …
accomplices to help tumors resist to immunity-induced apoptosis and promote tumor …
TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection
F Alfei, K Kanev, M Hofmann, M Wu, HE Ghoneim… - Nature, 2019 - nature.com
Cytotoxic T cells are essential mediators of protective immunity to viral infection and
malignant tumours and are a key target of immunotherapy approaches. However, prolonged …
malignant tumours and are a key target of immunotherapy approaches. However, prolonged …